Lipocalin-2 {90000390}
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| Definition: | Lipocalin-2 |
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| Function: | Pro-inflammatory |
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Shared Reference Notes
- [1.1] [#Multiple Sclerosis]
- bacteria thought to be beneficial for inflammatory bowel disease (IBD) such as #Anaerobutyricum, #Blautia, and #Roseburia, were reduced in fecal Lcn-2-high MS patients. - [#Multiple Sclerosis] - decreasing trend in serum #Acetate (a short-chain fatty acid) levels in MS Lcn-2-high patients compared to healthy donors (HDs). - a decrease in the relative abundance of #Blautia massiliensis was significantly associated with a reduction of #Acetate in the serum of MS patients.
- [#Multiple Sclerosis] - fecal Lipocalin-2 (Lcn-2), a biomarker of intestinal inflammation, was significantly elevated and predominantly produced by the gut-infiltrating neutrophils. - The elevation of fecal Lcn-2 levels correlated with reduced bacterial diversity and increased levels of other intestinal inflammation markers including neutrophil elastase and #Calprotectin.
References Notes
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