Disease ⇒ Drug-resistant Epilepsy {40000395} Record Keys Type:Disease Parent:[ ] Definition:Drug-resistant Epilepsy Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10015037 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Keto diet] - ketogenic diet has been shown to increase the level of #GABA in the cerebrospinal fluid of children with refractory epilepsy [1.2] [#Keto diet] - The ketogenic diet (KD) has shown excellent performance in the treatment of refractory epilepsy [1.3] [#Keto diet] - #Reactive Oxygen Species is elevated during #Seizure activity due to #Oxidative stress-associated neuronal death, which can further contribute to epileptogenesis. - The KD reportedly reduces #Oxidative stress by promoting antioxidant enzymatic activity. [#Keto diet] - Abnormal regulation of TORC1 signaling has been implicated in many epilepsies and is a therapeutic target. - The KD and select fatty acids inhibit TORC1 activity, [#Keto diet] - Microbial genes related to fatty acid β-oxidation, 2-methylcitrate cycle, glycol metabolism, and #Proline biosynthesis were more highly represented in the gut microbiota of epileptic #Children after treatment with the KD compared to their internal pre-treatment controlsReferences Notes[ ]
