Blautia ⇒ Hungatella hathewayi {10001879} Record Keys Parent:Blautia Definition:Hungatella hathewayi Details Initialisation date:2020-10-23 Meta Information Rank: Species Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Crohn’s disease, #Inflamatory bowel disease] [#Escherichia coli] - H. hathewayi transcript as belonging to the TIGR02037 family, which includes both K04771 and K04772 . - Proteases from these families are found in pathogens, such as Enteropathogenic E. coli (EPEC) and #Helicobacter pylori, where they have been described as virulence factors, shown to degrade E-cadherin,Citation46 and hypothesized to cleave PAR2. [#Inflamatory bowel disease] - Hungatella hathewayi to be increased compositionally and transcriptionally in IBD patients, suggesting high metabolic activity of the species during inflammation. - protease K04772 of H. hathewayi is actively transcribed in samples from CD-HPA colonized mice compared with CD-LPA colonized mice. [1.2] [#Colorectal cancer] [#Teenager] - well-known CRC-associated taxa, such as #Clostridium symbiosum, #Peptostreptococcus stomatis, #Parvimonas micra and Hungatella hathewayi were significantly enriched in both old- and young-onset patients. - Similar strain-level patterns of #Fusobacterium nucleatum, #Bacteroides fragilis and #Escherichia coli were observed for oCRC and yCRC. - Almost all oCRC-associated metagenomic pathways had directionally concordant changes in young patients.References Notes[ ]
