Blautia ⇒ Blautia wexlerae {10001360}

Shared Reference Notes

• [1.1] 
  - The abundances of Blautia wexlerae were linked to high blood levels of metabolites associated with several chronic diseases.
• [1.2] [#Diabetes Type 2] [#Oral administration of Blautia wexlerae] 
  - Blautia genus, especially B. wexlerae, as a commensal bacterium that is inversely correlated with #Obesity and type 2 diabetes mellitus. - Oral administration of B. wexlerae to mice induce metabolic changes and anti-inflammatory effects that decrease both high-fat diet–induced #Obesity and diabetes. - The beneficial effects of B. wexlerae are correlated with unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and L-ornithine and carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate, with simultaneous modification of the gut bacterial composition. - S-adenosylmethionine, acetylcholine, and L-ornithine have anti-inflammatory properties and modify aspects of host metabolism, such as lipid metabolism, indicating that these compounds are potential effector metabolites for controlling #Obesity and diabetes.
• [1.3] [#Multiple Sclerosis] [#Erysipelotrichaceae CCMM] 
  - In both progressive MS and RRMS > increased #Clostridium bolteae, #Ruthenibacterium lactatiformans, and #Akkermansia and decreased #Blautia wexlerae, #Dorea formicigenerans, and #Erysipelotrichaceae CCMM. - Unique to progressive MS, has elevated Enterobacteriaceae and Clostridium g24 FCEY and decreased #Blautia and #Agathobaculum.
• [1.4] [#Parkinson’s Disease] 
  - At one end of the spectrum, #Bifidobacterium dentium was elevated by 7-fold, #Actinomyces oris by 6.5-fold, #Streptococcus mutans by 6-fold. At the other end of the spectrum, #Roseburia intestinalis was reduced by 7.5-fold, and Blautia wexlerae by 5-fold.
• [1.5] [#Allergy] [#Anaerostipes hadrus, #Clostridium innocuum, #Eggerthella lenta, #Enterococcus faecalis, #Escherichia coli, #Eubacterium hallii, #Fusicatenibacter saccharivorans, #Tyzzerella nexilis] 
  - depletions in the bacterial species A. hadrus, F. saccharivorans, E. hallii, and B. wexlerae in participants who later developed allergic diseases, as well as enrichments in E. lenta, C. innocuum, E. faecalis, E. coli, and T. nexilis in these participants.
• [#Anaerostipes hadrus, #Eubacterium hallii, #Fusicatenibacter saccharivorans] [#Short Chain Fatty Acid] - The depleted bacterial populations are known short-chain fatty acid (SCFA) producers, notably the #Butyrate producers A. hadrus, E. hallii, and F. saccharivorans and the #Acetate producer B. wexlerae - depletion of #Butyrate in #Allergy-prone participants significant associations between A. hadrus and F. saccharivorans respective relative abundance and #Butyrate concentration.
• [1.6] [#Cognitive impairment] 
  - #Alistipes obesi, Blautia wexlerae, and #Ruminococcus gnavus were enriched or depleted in #Children with higher cognitive function scores.
• [#Cognitive impairment] [#Anaerostipes hadrus] - B. wexlerae and A. hadrus were among the top 15% important predictors on both left and right thalamus and the expressive language subscale.
• [#Cognitive impairment] [#Bacteroides finegoldii, #Roseburia faecis] - B. wexlerae, #Dorea longicatena, R. faecis, and A. finegoldii, are #Clostridiales > positively associated with cognitive function in children.

References Notes