Uric acid {90000593} Record Keys Parent:[ ] Definition:Uric acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Short Chain Fatty Acid] - a large number of gut bacteria consume uric acid anaerobically, converting it to either #Xanthine or #Lactate and the short chain fatty acids (SCFAs), #Acetate and #Butyrate. - #Clostridium cylindrosporum established the enzymatic activities involved in anaerobic #Purine metabolism [#Antibiotic Therapy] - Ablation of the microbiota in uricase-deficient mice causes severe #Hyperuricemia - anaerobe-targeted antibiotics increase the risk of #Gout in humans. [#Gout] [#Xanthine] - uric acid elimination is facilitated by the enzyme uricase. - Human uricase is a pseudogene, having been inactivated early in hominid evolution. - anaerobic uric acid metabolism is widespread among members of the human gut. [1.2] - #Kefir reduced triglycerides, uric acid, and affected the microbiome of animals increasing fecal #Butyrate-producing bacteria (#Lachnospiraceae and #Lachnoclostridium). [1.3] [#Hyperuricemia] [#Alistipes indistinctus] - #Hippuric acid functioned as the key microbial effector of A. indistinctus to lower UA. [#Alistipes indistinctus] - Replenishment of A. indistinctus and #Hippuric acid alleviated #Hyperuricemia via enhancing ABCG2-mediated intestinal UA excretion. [#Hyperuricemia] [#Urolithin A] - #Alistipes indistinctus (A. indistinctus) was found to be a keystone bacterium for maintaining optimal UA > lower UA. - the phenotype of elevated UA was transmissible with fecal microbial transplantation from donors with #Hyperuricemia.References Notes[ ]
