Sign ⇒ Acute anterior uveitis {40000578}

Shared Reference Notes

• [1.1] [#Ankylosing spondylitis, #Crohn’s disease, #HLA-B27-associated disease, #Psoriasis, #Psoriatic Arthritis, #Ulcerative Colitis] 
  - HLA-B27 transgenic rats that develop a spontaneous spondyloarthropathy-like illness do not develop disease when raised in a germ-free environment, but mono-association with #Phocaeicola vulgatus is sufficient to induce disease.
• [1.2] [#Inflamatory bowel disease] 
  - HLA-B27 spondyloarthropathies (SpA) > #Ankylosing spondylitis, #Reactive arthritis, #Psoriatic Arthritis, #Juvenile idiopathic arthritis, inflammatory bowel disease, acute anterior uveitis, and undifferentiated SpA > segmented filamentous bacteria (SFB) have been illustrated to be a common culprit in initiating an arthritogenic reaction. - The Th17 response, induced in the mesenteric lymph nodes by dendritic cells, in such patients specifically targets SFB, resulting in a breach in the mucosal barrier. - This is thought to result from cross-reactivity between HLA-B27 and pathogenic surface antigens. - Other enteric gram-negative pathogens, which mimic HLA-B27, associated with SpA and uveitis include #Shigella, #Chlamydia and #Yersinia
• [1.3] 
  - Patients with axial #Spondyloarthritis (SpA), acute anterior uveitis (AAU), and #Crohn’s disease > low abundances of #Lachnospiraceae taxa relative to controls, most notably #Fusicatenibacter, which was most abundant in controls receiving NSAID monotherapy and implied to partially mediate higher #Serum CRP.
• [1.4] [#Ankylosing spondylitis, #Vogt-Koyanagi-Harada] 
  - Six microbes (#Pediococcus, #Pseudomonas, #Rhodococcus, Photobacterium, #Gardnerella and Lawsonia) and two metabolites (pyrimidine and gallocatechin) as biomarkers could effectively distinguish patients with VKH from patients with AAU and healthy individuals

References Notes