Castalagin {90000247} Record Keys Parent:[ ] Definition:Castalagin Queue:[ ] Details Initialisation date:2022-01-17 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - Castalagin induced metabolic changes > resulting in an increase in #Taurine conjugated #Bile Acids. Oral supplementation of castalagin following fecal microbiota transplantation from ICI-refractory patients into mice supported anti-PD-1 activity. [#Cancer] - Oral administration of castalagin > enriched for bacteria associated with efficient immunotherapeutic responses (#Ruminococcaceae and #Alistipes) and improved the CD8+/Foxp3+CD4+ ratio within the tumor microenvironment. [#Cancer] [#Bile Acids, #Polyphenols] [#Polyphenol-rich supplementation] - oral supplementation with the polyphenol-rich berry camu-camu (CC, Myrciaria dubia) in mice > shifted gut microbial composition, which translated into antitumor activity and a stronger anti-PD-1 response. [#Cancer] - Castalagin binds to #Ruminococcus bromii and promoted an anticancer response.References Notes[ ]
