ICI therapy {51111420} Record Keys Definition:ICI therapy Queue:[ ] Details Initialisation date:[ ] Specification: [ ] Meta Information Type:[ ] Host:[ ] Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Bacteroides fragilis] - Bacteroides thetalotaomicron and fragilis with increased anti-CTLA-4 efficacy - #Bifidobacterium species to be associated with increased anti-PD-L1 activity - Certain commensal bacteria synthesize the metabolite #Inosine, which may enhance the efficacy of ICI therapy [1.2] [#Ruminococcaceae] - #Bacteroidetes remained the most common gut bacteria with increased levels of Ruminococcacae and #Akkermansia muciniphila after treatment which is in contrast to patients who did not respond to anti-PD-1 therapy and had increasing levels of #Proteobacteria after treatment, [1.3] [#immune-mediated Colitis] [#Fecal Microbiota Transplantation] - FMT from healthy donors as salvage therapy > ICI Therapy patient > 92% achieved IMC clinical remission.References Notes[ ]
