Candida ⇒ Candida tropicalis {10000117} Record Keys Parent:Candida Definition:Candida tropicalis Details Initialisation date:2020-09-06 Meta Information Rank: Species Domain:Fungi Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Colitis, #Crohn’s disease] - C. tropicalis > induces dysbiosis that involves changes in the presence of mucin-degrading bacteria #Akkermansia muciniphila and #Ruminococcus gnavus > leading to altered tight junction protein expression with increased intestinal permeability > followed by induction of robust Th1/Th17 responses > lead to an accelerated proinflammatory phenotype in experimental colitic mice. [1.2] [#Crohn’s disease] [#Candida albicans, #Candida glabrata] - #Candida. A common, although not universal, finding has been an increase, statistically significant or trending, in the relative amount of #Candida in the fecal mycobiome of patients with CD from diverse geographic locations. - The named species is usually C. albicans, but C. tropicalis and C. glabrata have also been reported. [1.3] [#Crohn’s disease] - depletion of Ca tropicalis in patients with isolated ileal CD compared with patients with colonic involvement [#Crohn’s disease] - patients with CD have much higher abundance of Ca tropicalis compared with their first-degree relatives without CD, - Ca tropicalis induces dysbiosis leading to increased intestinal permeability and induces T helper 1/T helper 17 responses in mice. [#Crohn’s disease] - a marked depletion of Ca tropicalis in those CD patients requiring surgery during disease course. [1.4] [#Cancer] - #Aspergillus fumigatus, C. tropicalis, and #Acremonium exuviarum, all labelled as “oncogenic fungi” [1.5] [#Attention Deficit Hyperactivity Disorder] - The abundance of Candida (especially #Candida albicans and and C. tropicalis was significantly increased in ADHD patients compared to the healthy controls. - C. albicans secretions significantly enhanced the permeability of Caco-2 cells.References Notes[ ]
