Disease ⇒ Psoriasis ⇒ Psoriatic Arthritis {40000279}

Shared Reference Notes

• [1.1] [#Acute anterior uveitis, #Ankylosing spondylitis, #Crohn’s disease, #HLA-B27-associated disease, #Psoriasis, #Ulcerative Colitis] 
  - HLA-B27 transgenic rats that develop a spontaneous spondyloarthropathy-like illness do not develop disease when raised in a germ-free environment, but mono-association with #Phocaeicola vulgatus is sufficient to induce disease.
• [1.2] 
  - #Kocuria and #Cutibacterium were enriched in healthy subjects, while #Staphylococcus was enriched in psoriatic disease. - The relative abundance of #Corynebacterium was higher in NL psoriatic arthritis (PsA). samples compared with NL #Psoriasis (PsO) samples.
• [1.3] [#Inflamatory bowel disease] 
  - HLA-B27 spondyloarthropathies (SpA) > #Ankylosing spondylitis, #Reactive arthritis, psoriatic arthritis, #Juvenile idiopathic arthritis, inflammatory bowel disease, #Acute anterior uveitis, and undifferentiated SpA > segmented filamentous bacteria (SFB) have been illustrated to be a common culprit in initiating an arthritogenic reaction. - The Th17 response, induced in the mesenteric lymph nodes by dendritic cells, in such patients specifically targets SFB, resulting in a breach in the mucosal barrier. - This is thought to result from cross-reactivity between HLA-B27 and pathogenic surface antigens. - Other enteric gram-negative pathogens, which mimic HLA-B27, associated with SpA and uveitis include #Shigella, #Chlamydia and #Yersinia
• [1.4] 
  - In patients with psoriatic arthritis, there was a decrease in the abundance of certain bacteria such as #Akkermansia, #Ruminococcus, #Pseudobotyrivibrio, #Paraacteroides, #Alistipes, and #Coprococcus

References Notes