Poly-unsaturated fatty acid {90000243} Record Keys Parent:[ ] Definition:Poly-unsaturated fatty acid Queue:[ ] Details Initialisation date:2022-01-13 Specification: [ ]Source: [ ] Meta Information Structural Type:Lipid Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Alzheimer’s disease] - Absence of gut microbiota > prominent reduction of cerebral amyloid-β plaques and neurofibrillary tangles pathology - absence of gut microbiota > altered inflammatory pathway and insulin/IGF-1 signalling in hippocampus. - Poly-unsaturated fatty acid metabolites identified by metabolomic analysis, and their oxidative enzymes were selectively elevated, corresponding with microglia activation and inflammation. - AD patients’ gut microbiome exacerbated AD pathologies in 3×Tg mice, associated with C/EBPβ/asparagine endopeptidase pathway activation and cognitive dysfunctions compared with healthy donors’ microbiota transplants. [1.2] [#High satureted fat diet] Presence of #Akkermansia showed positive correlation with intake of saturated fats and negative correlation with respect to polyunsaturated fatty acids (PUFA) present in overall diet.References Notes[ ]
