Poly-unsaturated fatty acid {90000243}

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Poly-unsaturated fatty acid
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Shared Reference Notes

  • [1.1] [#Alzheimer’s disease
    - Absence of gut microbiota > prominent reduction of cerebral amyloid-β plaques and neurofibrillary tangles pathology - absence of gut microbiota > altered inflammatory pathway and insulin/IGF-1 signalling in hippocampus. - Poly-unsaturated fatty acid metabolites identified by metabolomic analysis, and their oxidative enzymes were selectively elevated, corresponding with microglia activation and inflammation. - AD patients’ gut microbiome exacerbated AD pathologies in 3×Tg mice, associated with C/EBPβ/asparagine endopeptidase pathway activation and cognitive dysfunctions compared with healthy donors’ microbiota transplants.
  • [1.2] [#High satureted fat diet
    Presence of #Akkermansia showed positive correlation with intake of saturated fats and negative correlation with respect to polyunsaturated fatty acids (PUFA) present in overall diet.

References Notes

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