Poly-unsaturated fatty acid {90000243}
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| Definition: | Poly-unsaturated fatty acid |
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| Initialisation date: | 2022-01-13 |
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| Structural Type: | Lipid |
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Shared Reference Notes
- [1.1] [#Alzheimer’s disease]
- Absence of gut microbiota > prominent reduction of cerebral amyloid-β plaques and neurofibrillary tangles pathology - absence of gut microbiota > altered inflammatory pathway and insulin/IGF-1 signalling in hippocampus. - Poly-unsaturated fatty acid metabolites identified by metabolomic analysis, and their oxidative enzymes were selectively elevated, corresponding with microglia activation and inflammation. - AD patients’ gut microbiome exacerbated AD pathologies in 3×Tg mice, associated with C/EBPβ/asparagine endopeptidase pathway activation and cognitive dysfunctions compared with healthy donors’ microbiota transplants. - [1.2] [#High satureted fat diet]
Presence of #Akkermansia showed positive correlation with intake of saturated fats and negative correlation with respect to polyunsaturated fatty acids (PUFA) present in overall diet.
References Notes
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