Sulfide {60000040} Record Keys Parent:[ ] Definition:Sulfide Queue:[ ] Details Initialisation date:2020-09-17 Specification: [ ]Source: [ ] LinksInfolink Meta Information Structural Type:Inorganic Functional Type:[ ] Function:Pro-inflammatory, Oncogenesis, Genotoxin Notes: [ ]Shared Reference Notes [1.1] - Gut microbiota metabolize taurine and produce hydrogen sulfide gas. - Hydrogen sulfide inhibits aerobic respiration, and can thereby block the growth of harmful bacteria. [1.2] - #Animal-based diet could enrich the gut microbiome–encoding sulfite reductases and sulfite-reducing bacteria which generate hydrogen sulfide in sulfur metabolism, a harmful by-product that may induce DNA damage, disrupt the mucus bilayer, and promote inflammation and CRC. [1.3] [#Hydrogen sulfide] - Some oral #Bacteria (e.g., #Porphyromonas gingivalis, #Prevotella intermedia, #Aggregatibacter actinomycetemcomitans, and #Fusobacterium nucleatum) produce volatile #Sulfur compounds (VSCs), such as hydrogen sulfide (H2S), methyl mercaptan (CH3SH), dimethyl sulfide ((CH3)2S), and dimethyl disulfide (CH3SSCH3). - H2S is a known genotoxic agent and may lead to genomic instability or cumulative mutations. - Increased expression of various H2S-producing enzymes has been observed in #Cancer cells, particularly in cancers of the colon and ovaries. - Overexpression of cystathionine-β-synthase causes the production of increased amounts of H2S, which affect tumor growth and spread by activation of proliferation, migration, and invasive signaling pathways, and enhance tumor angiogenesisReferences Notes[ ]
