Salmonella ⇒ Salmonella typhimurium {10000155}
| Parent: | |
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| Definition: | Salmonella typhimurium |
| Initialisation date: | 2020-09-06 |
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| Rank: | Species |
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| Domain: | Bacteria |
| Zone: | [ ] |
| Enzyme: | [ ] |
| Function: | [ ] |
Notes:
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Shared Reference Notes
- [1.1]
- S. typhimurium, an intracellular pathogen, is chemoattracted to, and retained in, tumors due to the presence of metabolites produced by quiescent #Cancer cells within the TME (Tumor Micro envirounment). - Once in the tumor, S. typhimurium continues to proliferate and directly kills #Cancer cells by triggering of apoptosis, necrosis, and cell rupture. - S. typhimurium flagellin has been found to mount the antitumor response of CD8+ T and Natural Killer (NK) cells and to reduce the frequency of regulatory T cells (Tregs) - [1.2] [#Inflamatory bowel disease]
- adherent-invasive #Escherichia coli (AIEC), and Salmonella enterica serovar Typhimurium > induce inflammation (through elevated T helper (TH) 1 and TH17 immune responses) in IBD animal model > fibrosis development. - in patients with #Crohn’s disease, AIEC strains > ileal mucosa > trigger the initiation or perpetuation of the inflammatory disease. - [1.3] [#Short Chain Fatty Acid]
- SCFAs have been confirmed to display antibacterial activity by disturbing the intracellular acid-alkaline balance or acylating certain virulence factors of Salmonella typhimurium
References Notes
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