Epigallocatechin gallate {90000454}

Shared Reference Notes

• [1.1] 
  - a #Pomegranate extract was shown to reduce microgliosis and #Amyloid-beta plaque deposition in association with reduced #Anxiety-like behavior and increased memory performance. - This effect was attributed to two polyphenolic compounds, #Punicalagin and #Ellagic acid, and likely its bioactive microbial-derived metabolite EGCG
• [#Catechins, #Lipopolysaccharide] - A major #Green Tea catechin, epigallocatechin gallate (EGCG) has many neuroprotective abilities, neuroinflammation being just one of them. Pretreatment of outbred ICR mice with EGCG for 3 weeks (1.5 and 3 mg/kg/day) prior to LPS injection for 7 days prevented the LPS-induced memory impairment and apoptotic neuronal cell death.
• [#Lipopolysaccharide] - Similar to EGCG, #Resveratrol was shown in neuron-glial primary cultures to inhibit LPS-induced microglial activation and subsequent production of TNFα, #Nitric Oxide and IL-1β likely through modulation of inflammasome signaling

References Notes