Polyphenols ⇒ Epigallocatechin gallate {90000454}

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Epigallocatechin gallate
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Shared Reference Notes


  • [1.1] [#Short Chain Fatty Acid
    - ECGC contribute significantly also to increase the number of SCFAs-producing bacteria, especially #Akkermansia, enhancing the colon barrier integrity and general anti-inflammatory effects.
  • - Epigallocatechin gallate (ECGC) exert strong antimicrobial properties, binding to the #Staphylococcus aureus peptidoglycan and destroying the osmotic protection of the cell wall.
  • [1.2
    - a #Pomegranate extract was shown to reduce microgliosis and #Amyloid-beta plaque deposition in association with reduced #Anxiety-like behavior and increased memory performance. - This effect was attributed to two polyphenolic compounds, #Punicalagin and #Ellagic acid, and likely its bioactive microbial-derived metabolite EGCG
  • [#Catechins, #Lipopolysaccharide] - A major #Green Tea catechin, epigallocatechin gallate (EGCG) has many neuroprotective abilities, neuroinflammation being just one of them. Pretreatment of outbred ICR mice with EGCG for 3 weeks (1.5 and 3 mg/kg/day) prior to LPS injection for 7 days prevented the LPS-induced memory impairment and apoptotic neuronal cell death.
  • [#Lipopolysaccharide] - Similar to EGCG, #Resveratrol was shown in neuron-glial primary cultures to inhibit LPS-induced microglial activation and subsequent production of TNFα, #Nitric Oxide and IL-1β likely through modulation of inflammasome signaling
  • [1.3
    - epigallocatechin gallate, a plant-derived dietary polypheno can prevent pathology and motor symptoms in Thy1-SNCA mice by blocking amyloidogenic subunit of #Curli fibers (CsgA) amyloidogenesis and repressing CsgA transcript expression in #Escherichia coli
  • [1.4] [#Multiple Sclerosis] [#Hesperidin
    - EGCG, #Curcumin and hesperidin > attenuate EAE clinical severity or inhibit its development by reducing immune cell infiltration. - The latter two also seem to impact the Th17/Treg balance in EAE animals, promoting Treg cell expansion and Th17 suppression in the spleen, lymph nodes and the CNS, accompanied by repressed pro-inflammatory cytokine secretion
  • [#Multiple Sclerosis] - EGCG as well as #Naringenin for instance are known to impact the Th1-mediated immune response associated with EAE

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Common References


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