Polyphenols ⇒ Epigallocatechin gallate {90000454} Record Keys Parent:Polyphenols Definition:Epigallocatechin gallate Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Short Chain Fatty Acid] - ECGC contribute significantly also to increase the number of SCFAs-producing bacteria, especially #Akkermansia, enhancing the colon barrier integrity and general anti-inflammatory effects. - Epigallocatechin gallate (ECGC) exert strong antimicrobial properties, binding to the #Staphylococcus aureus peptidoglycan and destroying the osmotic protection of the cell wall. [1.2] - a #Pomegranate extract was shown to reduce microgliosis and #Amyloid-beta plaque deposition in association with reduced #Anxiety-like behavior and increased memory performance. - This effect was attributed to two polyphenolic compounds, #Punicalagin and #Ellagic acid, and likely its bioactive microbial-derived metabolite EGCG [#Catechins, #Lipopolysaccharide] - A major #Green Tea catechin, epigallocatechin gallate (EGCG) has many neuroprotective abilities, neuroinflammation being just one of them. Pretreatment of outbred ICR mice with EGCG for 3 weeks (1.5 and 3 mg/kg/day) prior to LPS injection for 7 days prevented the LPS-induced memory impairment and apoptotic neuronal cell death. [#Lipopolysaccharide] - Similar to EGCG, #Resveratrol was shown in neuron-glial primary cultures to inhibit LPS-induced microglial activation and subsequent production of TNFα, #Nitric Oxide and IL-1β likely through modulation of inflammasome signaling [1.3] - epigallocatechin gallate, a plant-derived dietary polypheno can prevent pathology and motor symptoms in Thy1-SNCA mice by blocking amyloidogenic subunit of #Curli fibers (CsgA) amyloidogenesis and repressing CsgA transcript expression in #Escherichia coli [1.4] [#Multiple Sclerosis] [#Hesperidin ] - EGCG, #Curcumin and hesperidin > attenuate EAE clinical severity or inhibit its development by reducing immune cell infiltration. - The latter two also seem to impact the Th17/Treg balance in EAE animals, promoting Treg cell expansion and Th17 suppression in the spleen, lymph nodes and the CNS, accompanied by repressed pro-inflammatory cytokine secretion [#Multiple Sclerosis] - EGCG as well as #Naringenin for instance are known to impact the Th1-mediated immune response associated with EAEReferences Notes[ ]
