Disease ⇒ Parkinson's Disease ⇒ Idiopathic rapid-eye-movement sleep behavior disorder {40000515} Record Keys Type:Disease Parent:Parkinson’s Disease Definition:Idiopathic rapid-eye-movement sleep behavior disorder Details Initialisation date:2020-12-09 Other Terms:iRBD Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:Ophtalmology, Neurology Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - RBD is characterized by dream-enactment behaviors during the rapid-eye-movement sleep, when normal people lose muscle tone, called a state of atonia. - RBD is categorized into idiopathic RBD (iRBD) and symptomatic RBD. The prevalence of iRBD is estimated to be 0.5 to 2%. - iRBD frequently predisposes to neurodegenerative α-synucleinopathies including PD, dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). - iRBD patients sometimes have subtle sensory, motor, and cognitive deficits, as well as constipation, before the onset of PD and other α-synucleinopathies. - PD has been classified into three groups according as the disease progresses: preclinical PD (no overt symptoms even in the presence of neurodegeneration), prodromal PD (overt symptoms but lacking the criteria of PD), and clinical PD (overt symptoms satisfying the criteria of PD). - iRBD is the most dependable hallmark of prodromal PD. - Similarly, the likelihood ratio of iRBD to develop PD is as high as 130 Thus, therapeutic intervention to prevent transition from iRBD to PD has a potential to become a causative treatment for PD. - Genus Akkermansia may increase the intestinal permeability, as observed in PD patients, and may make the intestinal neural plexus exposed to oxidative stress, which can lead to abnormal aggregation of prion-like α-synuclein fibrils in the intestine. - In contrast to PD, SCFA-producing bacteria are not decreased in iRBD. - As SCFA induces regulatory T (Treg) cells, a decrease of SCFA-producing bacteria may be a prerequisite for the development of PD. [1.2] [#Parkinson’s Disease] References Notes[ ]
