Vitamin A {90000286}

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Vitamin A
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Shared Reference Notes

  • [1.1] [#β-caroten
    - Vitamin A deficiency (VAD) results in intestinal inflammation, increased redox stress and reactive oxygen species (ROS) levels, imbalanced inflammatory and immunomodulatory cytokines, compromised barrier function, and perturbations of the gut microbiome. - #Dietary β-carotene also modified the taxonomic profile of the fecal microbiome, but only under VAD.
  • [1.2] [#Citrobacter rodentium
    - Commensal segmented filamentous bacteria protect against C. rodentium infection - Commensal bacteria express enzymes that generate #Retinoic acid in the intestine - Commensal bacterial-derived #Retinoic acid promotes epithelial defense in the host
  • [1.3
    - the predominant anti-inflammatory bacteria in the Vitamin A Normal group are #Akkermansia and #Verrucomicrobiales, while the anti-inflammatory bacterial communities in the VAS group belong to the genus #Desulfovibrio.
  • [#Amyloid-beta] - a deficiency in vitamin A leads to an elevation in serum pro-inflammatory cytokines TNF-α, IL-1β, and #IL-6 in APP/PS1 mice. - supplementation of vitamin A results in a decrease in these cytokines. - TNF-α has the ability to stimulate γ-secretase activity, which subsequently leads to an increased synthesis of Aβ peptides
  • [#Cognitive impairment] [#Amyloid-beta] - 12-week vitamin A-deficient diet resulted in decreased serum retinol levels, impaired cognition, and increased Aβ pathologies in the hippocampus of APP/PS1 mice.
  • [#Cognitive impairment] [#Amyloid-beta] - a vitamin A-enriched diet led to higher serum retinol levels, preserved cognition, and reduced Aβ pathologies in the hippocampus of APP/PS1 mice.
  • - the predominant pro-inflammatory bacteria in the Vitamin A Deficit group consist of microbial communities such as #Parabacteroides and #Tannerellaceae.
  • - Dietary vitamin A has the ability to influence the transcriptome of the intestine, thereby affecting the regulation of intestinal permeability and the release of inflammatory factors. - inadequate vitamin A levels can augment intestinal permeability, whereas vitamin A supplementation can ameliorate this phenomenon

References Notes

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