Iodine {90000530} Record Keys Parent:[ ] Definition:Iodine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Breast cancer] - I2 decreases the invasive potential of a triple negative basal #Cancer cell line, and under in vivo conditions the oral supplement of this halogen activates the antitumor immune response, preventing progression of xenografts from laminal and basal mammary #Cancer cells. [1.2] [#Omega 3] - iodine and omega-3 PUFA deficiencies are associated with #Hearing loss [1.3] [#Short Chain Fatty Acid] - SCFA-producing #Bacteria such as #Akkermansia, #Butyrivibrio, #Holdemania, #Anaerostipes, and #Intestinimonas were identified in this study as part of the gut microbiota associated with #Hypothyroidism. - SCFAs play a crucial role in the regulation of sodium/iodine symporter (NIS) expression in thyroid cells. [#Hypothyroidism] - the composition of the gut bacteria affects the uptake and movement of essential minerals such as iodine, copper, #Iron, #Zinc, and #Selenium, along with the required enzyme activity for synthesizing thyroid hormones. The conversion of thyroxine (T4) into active triiodothyronine (T3) or reverse T3 (rT3) heavily relies on iodothyronine-deiodinases. - The intestinal wall exhibits deiodinase activity, which possibly increases the overall amount of T3. - Animal models have demonstrated that individuals deficient in certain microorganisms have a reduced ability to absorb elemental iodine through the intestine [#Thyroid carcinoma] [#Short Chain Fatty Acid] - SCFA, particularly #Butyric acid, inhibits histone deacetylase (HDAC) and activates NIS re-expression in thyroid cancer cells, leading to redifferentiation and enhanced iodine uptake [1.4] - Thyroxine and thyroid function have been shown to be impacted by the gut microbes’ capacity to increase the bioavailability of trace micronutrients such as iodine, copper, and #Iron. - The microbiome change in response to stress may be exacerbating thyroid hormone imbalance perpetuating the change in #Anxiety-like behavior and future studies will examine this bidirectional cross talk. References Notes[ ]
