Disease ⇒ Skin wound {40000635} Record Keys Type:Disease Parent:[ ] Definition:Skin wound Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - topical #Resveratrol treatment exhibited a significant antimicrobial efficacy against #Staphylococcus aureus, #Pseudomonas aeruginosa, and #Candida albicans, which are discussed as significant pathogens in the context of non-healing wounds. - Resveratrols’ antimicrobial effects seemed to be even superior than some commercial antimicrobial (Levomecol) and antifungal (Clotrimazole) ointments. - anti-inflammatory and wound healing effects of #Resveratrol depend rather on their interaction with epidermal growth factor receptor (EGFR)-controlled cytoplasmic and nuclear pathways than on their direct antioxidant and free radical scavenging activity. - significantly improved wound healing following #Resveratrol application based on antioxidant activity. - #Resveratrol induces vascular endothelial growth factor (VEGF) expression and subsequently regulates angiogenesis. [#Sirtuin] - proangiogenic properties of #Resveratrol> activation of SIRT1 > SIRT1 is associated with the induction of angiogenesis, fibroplasia, and collagen organisation. [1.2] [#Cancer] - #Akkermansia is associated with enhancement of wound healing, augmented antitumor responses, protection against #Obesity, and induced intestinal adaptive immune responses during homeostasisReferences Notes[ ]
