Inosine {90000365} Record Keys Parent:[ ] Definition:Inosine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Immun regulator Notes: [ ]Shared Reference Notes [1.1] [#Bifidobacterium longum] [#Infants] - B. longum abundance was inversely correlated with inosine, a purine metabolite with immunoregulatory properties [1.2] - Certain commensal bacteria synthesize the metabolite inosine, which may enhance the efficacy of #ICI therapy [1.3] colistin has an impact on the immune microenvironment of the testis and can downregulate serum testosterone levels in male mice through inhibition of #Akkermansia, leading to destroyed inosine metabolism. Supplement with inosine can restore testosterone secretion probably by prompting the recovery of the intestinal mucus barrier and the serum lipopolysaccharides levels. [1.4] [#Cognitive impairment] - inosine was shown to improve cognitive function and to decrease neuroinflammation in ageing rats [#Multiple Sclerosis] - MS models predicted a large increase in the production of #Methanol and #Formaldehyde, and a decreased availability of inosine and #Deoxyinosine. [1.5] - soluble fiber #Inulin or #Guar gum, but not insoluble fiber cellulose, promoted colorectal tumorigenesis in AOM-treated and Apcmin/+ mice. - Soluble fiber induced gut dysbiosis with #Bacteroides uniformis enrichment and #Bifidobacterium pseudolongum depletion, accompanied by increased fecal #Butyrate and serum #Bile Acids and decreased inosine.References Notes[ ]
