Inosine {90000365} Record Keys Parent:[ ] Definition:Inosine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Immun regulator Notes: [ ]Shared Reference Notes [1.1] [#Bifidobacterium longum] [#Infants] - B. longum abundance was inversely correlated with inosine, a purine metabolite with immunoregulatory properties [1.2] - Certain commensal bacteria synthesize the metabolite inosine, which may enhance the efficacy of #ICI therapy [1.3] colistin has an impact on the immune microenvironment of the testis and can downregulate serum testosterone levels in male mice through inhibition of #Akkermansia, leading to destroyed inosine metabolism. Supplement with inosine can restore testosterone secretion probably by prompting the recovery of the intestinal mucus barrier and the serum lipopolysaccharides levels.References Notes[ ]