Non-nutritive Sweeteners {50000125} Record Keys Definition:Non-nutritive Sweeteners Queue:[ ] Details Initialisation date:2019-06-23 Specification: Sugar substitute LinksInfolink Meta Information Type:Diet Host: Mouse Notes: - Microbiome profiling confirmed a significant increase in firmicutes and a striking decrease of Akkermansia muciniphila. Similar microbiome alterations in humans have been linked to metabolic disease and obesity. - Akkermansia muciniphila is transmitted but does not consistently colonize pups born to NNS-exposed mothers. Akkermansia muciniphila, depleted in NNS pups, is a beneficial bacterium associated with a young and lean metabolism, inversely correlated with fat mass gain, type 1 diabetes and Inflammatory bowel syndrome . - pre- and post-natal exposure to sucralose and acesulfame-K via maternal ingestion causes marked metabolic and microbiome alterations in the pups (1)Shared Reference Notes [1.1] [1.2] [1.3] [#Sweeteners] - Notable oral microbiome alterations include changes in relative abundances of six Streptococcus species in the #Sucralose group , reduced relative abundance of Fusobacterium in the saccharin group, and reduced abundance of Porphyromonas and Prevotella nanceiensis in the aspartame group [1.4] [#Sweeteners] - the #Fasting #Glucose concentrations and the abundances of #Enterobacteriaceae and #Clostridium leptum were increased in diet-induced #Obesity models treated with aspartame for eight weeks [1.5] - all ArtSw exposures were related to higher BMI, body weight, and waist circumference and, except for #Sucralose, were associated with increases in these anthropometric measurements over a 25-year period. - Greater risks of developing #Obesity were found across increasing quintiles of total ArtSw, aspartame, #Sucralose, and diet beverage intakes.References Notes (1) [1.6]
