Non-nutritive Sweeteners {50000125}

Record Keys
Definition:
Non-nutritive Sweeteners
Queue:[  ]

Details
Initialisation date:
2019-06-23
Specification:

Sugar substitute

Links

Meta Information
Type:
Diet
Host:
 Mouse

Notes:

- Microbiome profiling confirmed a significant increase in firmicutes and a striking decrease of Akkermansia muciniphila. Similar microbiome alterations in humans have been linked to metabolic disease and obesity.
- Akkermansia muciniphila is transmitted but does not consistently colonize pups born to NNS-exposed mothers.
Akkermansia muciniphila, depleted in NNS pups, is a beneficial bacterium associated with a young and lean metabolism, inversely correlated with fat mass gain, type 1 diabetes and Inflammatory bowel syndrome .
- pre- and post-natal exposure to sucralose and acesulfame-K via maternal ingestion causes marked metabolic and microbiome alterations in the pups (1)

Shared Reference Notes

  • [1.1] 
  • [1.2] 
  • [1.3] [#Sweeteners] 
    - Notable oral microbiome alterations include changes in relative abundances of six Streptococcus species in the #Sucralose group , reduced relative abundance of Fusobacterium in the saccharin group, and reduced abundance of Porphyromonas and Prevotella nanceiensis in the aspartame group
  • [1.4] [#Sweeteners] 
    - the #Fasting #Glucose concentrations and the abundances of #Enterobacteriaceae and #Clostridium leptum were increased in diet-induced #Obesity models treated with aspartame for eight weeks
  • [1.5] 
    - all ArtSw exposures were related to higher BMI, body weight, and waist circumference and, except for #Sucralose, were associated with increases in these anthropometric measurements over a 25-year period. - Greater risks of developing #Obesity were found across increasing quintiles of total ArtSw, aspartame, #Sucralose, and diet beverage intakes.

References Notes

  • (1) [1.6] 
MetaBiom only uses strictly necessary session cookies to give you the best possible experience on the website. By selecting "Accept essential cookies" you agree to the use of these cookies.