Non-nutritive Sweeteners {50000125}
| Definition: | Non-nutritive Sweeteners |
|---|---|
| Queue: | [ ] |
| Initialisation date: | 2019-06-23 |
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| Specification: | |
Sugar substitute | |
| Type: | Diet |
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| Host: | Mouse |
Notes:
- Microbiome profiling confirmed a significant increase in firmicutes and a striking decrease of Akkermansia muciniphila. Similar microbiome alterations in humans have been linked to metabolic disease and obesity.
- Akkermansia muciniphila is transmitted but does not consistently colonize pups born to NNS-exposed mothers.
Akkermansia muciniphila, depleted in NNS pups, is a beneficial bacterium associated with a young and lean metabolism, inversely correlated with fat mass gain, type 1 diabetes and Inflammatory bowel syndrome .
- pre- and post-natal exposure to sucralose and acesulfame-K via maternal ingestion causes marked metabolic and microbiome alterations in the pups (1)
Shared Reference Notes
- [1.1]
- [1.2]
- [1.3] [#Sweeteners]
- Notable oral microbiome alterations include changes in relative abundances of six Streptococcus species in the sucralose group , reduced relative abundance of Fusobacterium in the saccharin group, and reduced abundance of Porphyromonas and Prevotella nanceiensis in the aspartame group
References Notes
- (1) [1.4]