Non-nutritive Sweeteners {50000125}

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Non-nutritive Sweeteners
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Sugar substitute


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- Microbiome profiling confirmed a significant increase in firmicutes and a striking decrease of Akkermansia muciniphila. Similar microbiome alterations in humans have been linked to metabolic disease and obesity.
- Akkermansia muciniphila is transmitted but does not consistently colonize pups born to NNS-exposed mothers.
Akkermansia muciniphila, depleted in NNS pups, is a beneficial bacterium associated with a young and lean metabolism, inversely correlated with fat mass gain, type 1 diabetes and Inflammatory bowel syndrome .
- pre- and post-natal exposure to sucralose and acesulfame-K via maternal ingestion causes marked metabolic and microbiome alterations in the pups (1)

Shared Reference Notes

  • [1.1
  • [1.2
  • [1.3] [#Sweeteners
    - Notable oral microbiome alterations include changes in relative abundances of six Streptococcus species in the #Sucralose group , reduced relative abundance of Fusobacterium in the saccharin group, and reduced abundance of Porphyromonas and Prevotella nanceiensis in the aspartame group
  • [1.4] [#Sweeteners
    - the #Fasting #Glucose concentrations and the abundances of #Enterobacteriaceae and #Clostridium leptum were increased in diet-induced #Obesity models treated with aspartame for eight weeks
  • [1.5
    - all ArtSw exposures were related to higher BMI, body weight, and waist circumference and, except for #Sucralose, were associated with increases in these anthropometric measurements over a 25-year period. - Greater risks of developing #Obesity were found across increasing quintiles of total ArtSw, aspartame, #Sucralose, and diet beverage intakes.

References Notes

  • (1) [1.6
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