Enterobacteriaceae ⇒ Salmonella {10000918}

Shared Reference Notes

• [1.1] 
  - Salmonella spp. also induce #Cancer cells to produce the gap junction protein, connexin 43, which enhances the transfer and cross-presentation of processed tumor antigenic peptides between #Cancer cells and dendritic cells (DCs), and reduce the expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO)
• [1.2] 
  - #Indole has antipathogenic potential toward Salmonella by reducing the expression of virulence genes. - #Indole also exerts anti-inflammatory properties by counteracting the lipopolysaccharide (LPS)-induced inflammatory response and inhibiting pro-inflammatory activation of macrophages.
• [1.3] [#Escherichia coli, #Helicobacter pylori, #Shigella flexneri] 
  - Notable genera in the #Proteobacteria are #Escherichia, Salmonella, #Shigella, #Desulfovibrio, and #Helicobacter. Included in the phyla is the #Enterobacteriaceae family, which contains several enteropathogenic bacteria, including #Shigella flexneri, Salmonella typhi, and #Escherichia coli. Other enteric pathogens in this phylum are #Vibrio cholerae and #Helicobacter pylori.
• [1.4] [#Salmonella typhimurium] 
  - increased abundance of Salmonella in the gut microbiome of patients with #Gallbladder cancer (GBC) and culturable Salmonella Typhimurium from their GBC tissue. - Comparative genomics of S. Typhimurium isolated from GBC tissue showed a high invasive index. S. Typhimurium isolates harbored horizontally acquired potential virulence functions in their accessory genome. - Chronic S. Typhimurium infection displayed inflammation, pre-neoplastic changes and tumor promoting mechanisms in a mouse model with gallbladder stones, including activation of the epigenetic modulator Kdm6b. Inhibition of Kdm6B reduced tumor size in NOZ cells engrafted in SCID-mice.
• [1.5] [#Short Chain Fatty Acid] 
  - An additional function of SCFAs is to lower the colonic luminal pH to inhibit growth of pathogens such as Salmonella and #Escherichia coli
• [1.6] 
  - #Mannose can reduce colonization of pathogens by promoting #Mannose adhesion to Salmonella. #Mannose binds to Salmonella via type 1 fimbriae
• [1.7] 
  - #Hydrogen sulfide may suppress the #Oxygen-dependent metabolism of some pathogens - #Taurinivorans muris has a protective role against #Klebsiella and Salmonella, two important gut pathogens.
• [1.8] [#Roseomonas mucosa] 
  - The #Segmented filamentous bacteria (SFB) can improve the immune response of mucosal tissues. - SFB are bacteria that can not be cultured present at weaning in the ileum of mice. - This bacterial species induces the immune response of the gut mucosa after birth. - In the absence of SFB, mice were found to possess reduced IgA titers and decreased numbers of helper T-cells (especially Th17 cells). - they had a weak response to intestinal pathogenic bacteria such as Salmonella and #Citrobacter rodentium
• [1.9] 
  - The dominant species identified in the bile of #Gallbladder cancer patients included #Fusobacterium nucleatum, #Escherichia coli, and #Enterobacter sp., while the bile from cholelithiasis patients primarily contained #Escherichia coli, Salmonella sp., and #Enterococcus gallinarum
• [#Attention Deficit Hyperactivity Disorder, #Autism] - The presence of strains related to Salmonella and #Citrobacter, labeled in this investigation as SREB, was significantly higher in #Infants who later developed comorbid ASD/ADHD (21%), compared to control
• [1.11] 
  - The efficacy of the #Copper beads was tested in vitro and in vivo. In vitro, Salmonella was significantly reduced when in contact with the #Copper beads solution for up to 6 h, with a 5.4 log CFU/mL reduction over the first hour.

References Notes