Hydrogen sulfide {90000132}

Shared Reference Notes

• [1.1] 
  - In the cardiovascular system, H2S plays important roles in the regulation of blood pressure, angiogenesis, smooth muscle cell proliferation and apoptosis, anti-oxidative stress, cardiac functions.
• [1.2] [#Alzheimer’s disease] 
  - H2S > important signaling molecule in organisms > improve the progression of AD by enhancing Nrf2 > reduce the production of Aβ by inhibiting β secretase 1 (BACE1) > and protect neurons by maintaining mitochondrial function
• [#Colorectal cancer] - H2S at a safe and nontoxic concentration can protect not only healthy cells, such as neurons, but also cancerous cells from apoptosis. - In a variety of cancers, including ovarian #Cancer, oral #Cancer, thyroid #Cancer, colon #Cancer, #Breast cancer, etc., the upregulation of H2S-producing enzyme CBS > can enhance the proliferation ability of #Cancer cells and make #Cancer cells more sensitive to it
• [1.3] [#Colorectal cancer] 
  - H2S increased the in vitro proliferation of human cells obtained from mucosal biopsies. - Interestingly, this effect was inhibited by #Butyrate.
• [#Colorectal cancer] - #Fusobacterium nucleatum, a Gram negative, anaerobic bacterium over-represented in CRC tissues, is a H2S-producer. - F. nucleatum also produces the metabolite #Formate, which triggers AhR and increases cancer cell stemness and invasiveness.
• [#Colorectal cancer] - Fecal H2S concentrations are elevated in CRC patients. - Increased levels of H2S can decrease tissue integrity by reducing disulfide bonds in mucosal tissues. - H2S can also directly cause DNA damage.

References Notes