IL-22 {60000055} Record Keys Parent:[ ] Definition:IL-22 Queue:[ ] Details Initialisation date:2020-09-16 Specification: [ ]Source: [ ] LinksInfolink Meta Information Structural Type:Protein Functional Type:Cytokine Function:Immun regulator, Enhancing Gut integrity Notes: [ ]Shared Reference Notes [1.1] [#Crohn’s disease] [#Condition of chronic stress] - Stress-exposed mice > develop ileal dysbiosis, dominated by the expansion of #Enterobacteriaceae. - Stress-induced glucocorticoids promote > apoptosis of CD45+CD90+ cells that normally produce IL-22, a cytokine that is essential for the maintenance of ileal mucosal barrier integrity. - Blockade of glucocorticoid signaling or administration of recombinant IL-22 > restores mucosal immunity, prevents ileal dysbiosis. [1.2] [#Polycystic ovary syndrome] - PCOS > reduction of bile acid (#Glycodeoxycholic acid and #Tauroursodeoxycholic acid) and IL-22 secretion - administration of #Chenodeoxycholic acid could improve PCOS phenotypes in mice experiments. [1.3] [#Multiple Sclerosis] - MS > bacterial species more abundant in clinically active treatment-naïve cases were positively associated with circulating levels of pro-inflammatory cytokines IL-22, #IL-17A, IFN-β, IL-33, and TNF-α. [1.4] [#Limosilactobacillus (Lactobacillus) reuteri] [#Indole-3-acetaldehyde] - Lactobacillus reuteri is known to be a common gut-dwelling strain that possesses the ability to produce (IAld) in the I3AA-dependet pathway. - This synthesis of IAld by L. reuteri results in #AHR-dependent IL-22 production and gut protection from inflammation, indicating IAld as a beneficial bacterial-derived metabolite.References Notes[ ]
