Disease ⇒ Cancer ⇒ Esophageal cancer {40000175} Record Keys Type:Disease Parent:Cancer Definition:Esophageal cancer Details Initialisation date:2020-09-01 Other Terms:[ ] LinksWickipediaMerck Manual Meta Information MedDra ID:10030155 MedDra Level:pt ICD:[ ] Category:Gastroenterology, Oncology Zone:[ ] Mechanism:[ ] Notes: - P. gingivalis was detected immunohistochemically in 61 % of cancerous tissues, 12 % of adjacent tissues and was undetected in normal esophageal mucosa. A similar distribution of lysine-specific gingipain, a catalytic endoprotease uniquely secreted by P. gingivalis, and P. gingivalis 16S rDNA was also observed. - P. gingivalis infection positively associated with multiple clinicopathologic characteristics, including differentiation status, metastasis, and overall survival rate. (1) Shared Reference Notes [1.1] - The presence of oral P. gingivalis and T. forsythia associate with an increased risk of esophageal cancer. - P. gingivalis and T. forsythia are included in signaling pathways responsible for cancer development. - T. forsythia may induce pro-inflammatory cytokines such as IL-1β and IL-6 by CD4 + T helper cells and TNF-α. - gingipain K produced by P. gingivalis, affects hosts immune system by degradation of immunoglobulins and complement system. [1.2] [#Cladosporium cladosporiode] - In a mouse model of esophageal cancer, oral fungi Cladosporium cladosporiodes reportedly increased the severity of ESCC, which was, interestingly reversed by antifungal treatment. - infections #HPV and #EBV reportedly increased risk of esophageal squamous cell carcinoma [1.3] [#Head & Neck cancer, #Oral cancer] - Among streptococci, #Streptococcus anginosus seems to be an especially relevant marker of head, neck, and esophageal cancers [1.4] [#Biliary tract cancer, #Colorectal cancer, #Gallbladder cancer, #Pancreatic Cancer] [1.5] [#Fusobacterium nucleatum] - F. nucleatum was suggested to be enriched in #Cervical cancer and esophageal cancer compared to adjacent healthy tissue. [1.6] [#Colorectal cancer, #Gastric carcinoma] - #Ferrichrome, produced by the #Probiotic #Lactobacillus casei, exhibited anti-tumor effects in various gastrointestinal cancers, including colorectal and gastric cancers, with minimal effects on non-cancerous intestinal cells. [#Esophageal squamous cell carcinoma] - #Ferrichrome suppressed esophageal adenocarcinoma (OE33, OE19) and squamous cell carcinoma (KYSE70) cells. References Notes[ ]
