Curli {90000130}

Shared Reference Notes

• [1.1] [#Parkinson’s Disease] [#Escherichia coli] 
  - 38 E. coli genes promote neurodegeneration. - Two of these genes, csgA and csgB, code for proteins that form curli, one type of bacterial amyloid fibers. - Curli cross-seeds and colocalizes with α-syn both in C. elegans neurons and human neuroblastoma cells. - Curli-induced α-syn aggregations down-regulate mitochondrial genes, causing energy failure in neurons. - Curli may have general effects in promoting neuropathologies induced by different aggregation-prone proteins, such as A-β in Alzheimer’s disease, Huntingtin in Huntington’s disease, and SOD1 in amyotrophic lateral sclerosis.
• [1.2] 
  - Curli fibers are produced by Enterobacteriaceae, Bacteroidetes, Proteobacteria, Firmicutes and Theromosulfobacteria. - Curli fibers are involved in cytokine production such as type I interferons, activate the Toll-like receptors TLR1 and TLR2 and the intracellular NLR family Pyrin Domain Containing 3 (NLRP3) inflammasome resulting in inflammation. - #Amyloid-producing bacteria have been described in systemic lupus erythematosus, reactive arthritis, neurodegenerative diseases, colorectal cancers and other diseases, and progress in understanding their contribution to disease pathogenesis will hopefully bring about potential therapies
• [1.3] [#Autism] [#Alpha-synuclein, #Amyloid, #Beta-glucan] [#Nichi Glucan] 
• [1.4] [#Parkinson’s Disease] 
  - curli, an amyloidogenic protein produced by Gram-negative Escherichia coli, induces #Alpha-synuclein aggregation and accelerates disease in the gut and neurodegeneration in the brain. - Many Enterobacteriaceae species encode curli.

References Notes