Sweeteners {51111268} Record Keys Definition:Sweeteners Queue:[ ] Details Initialisation date:2022-01-14 Specification: [ ] Meta Information Type:[ ] Host:[ ] Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Obesity] - Maternal consumption of sweeteners > altered cecal microbial composition and metabolism of #Propionate/#Lactate in their offspring. - Offspring daily body weight gain, liver weight and body fat > correlate positively to the relative abundance of key microbes and enzymes involved in #Succinate/#Propionate production while negatively correlated to that of #Lactose degradation and #Lactate production. - The altered #Propionate/#Lactate production in the cecum of weanlings from aspartame and stevia consuming dams implicates an altered ratio of dietary carbohydrate digestion, mainly #Lactose, in the small intestine vs. microbial fermentation in the large intestine. [1.2] [1.3] [#Non-nutritive Sweeteners] - Notable oral microbiome alterations include changes in relative abundances of six Streptococcus species in the #Sucralose group , reduced relative abundance of Fusobacterium in the saccharin group, and reduced abundance of Porphyromonas and Prevotella nanceiensis in the aspartame group [1.4] - People may also be exposed to even higher levels when gut bacteria convert #Sucralose into #Sucralose-6-acetate. - #Sucralose-6-acetate is an intermediate and impurity in the manufacture of #Sucralose. - #Sucralose-6-acetate is genotoxic. - #Sucralose-6-acetate significantly increased the expression of genes associated with inflammation, oxidative stress, and cancer with greatest expression for the metallothionein 1 G gene (MT1G). - #Sucralose-6-acetate and #Sucralose both impaired intestinal barrier integrity. - #Sucralose-6-acetate also inhibited two members of the cytochrome P450 family (CYP1A2 and CYP2C19). [1.5] [#Non-nutritive Sweeteners] - the #Fasting #Glucose concentrations and the abundances of #Enterobacteriaceae and #Clostridium leptum were increased in diet-induced #Obesity models treated with aspartame for eight weeks [1.6] - artificial sweeteners elicit purinergic transmission in the brain, which may be involved in the etiopathogenesis of #Depression. [#Ultra-processed food intake] - greater UPF intake, particularly artificial sweeteners and artificially sweetened beverages, is associated with increased risk of #Depression. [1.7] - The intake of the #Sucrose-sweetened beverage resulted in a significant increase in plasma endotoxin levels while being unchanged after the intake of #Sucralose-sweetened beverages. - an acute intake of physiologically relevant amounts of #Sucrose but not of #Sucralose can result in post-prandial endotoxemia.References Notes[ ]
