Proton pump inhibitors {51111404} Record Keys Definition:Proton pump inhibitors Queue:[ ] Details Initialisation date:[ ] Specification: [ ] Meta Information Type:[ ] Host:[ ] Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] - proton pump inhibitors (PPIs) users and #Achlorhydria patients exhibit an abnormal increase in gut colonization by oral pathobionts [1.2] [#Natural Small intestine Microbiome] - PPI > induce SI duodenal microbiota dysbiosis, characterized by an increase in #Akkermansia muciniphila and #Porphyromonas endodontalis and a decrease in #Enterococcaceae, #Coprococcus, #Enterobacteriaceae, and #Synergistes species [1.3] [#Aging] - use of prescribed PPIs for > 4.4 years by individuals ages 45 years and older is associated with a higher incidence (33% higher #Dementia risk) of newly diagnosed #Dementia. [1.4] - lower abundance in gut commensals and lower microbial diversity in PPI users, with an associated significant increase in the abundance of oral and upper GI tract commensals. - In particular, significant increases were observed in #Streptococcaceae. [1.5] [#Inflamatory bowel disease] - regular use of PPIs consistently showed a significantly positive association with IBD, #Crohn’s disease, and #Ulcerative Colitis risk - Direct comparison with H2 receptor antagonist, a less potent acid suppressor, showed that PPI use was also associated with higher IBD risk [1.6] [#Alzheimer’s disease] - PPIs can affect brain cells through various mechanisms, for example, by increasing beta-#Amyloid levels, involved in the development of AD. - PPI use was associated with an increased rate of all-cause #Dementia before age 90 years. - Associations displayed a duration-response pattern and were largest among the youngest cases of #Dementia (age 60 to 69 years at diagnosis) and decreased with advancing age at diagnosis. - PPI use showed risk estimates close to unity for #Dementia occurring in age 80 to 89 years. - The association between PPI use and #Dementia was unambiguously largest among the youngest cases of #Dementia - Listed side-effects of PPI use include neurological, psychological, and psychiatric symptoms/conditions.References Notes[ ]
