Alistipes ⇒ Alistipes indistinctus {10001097} Record Keys Parent:Alistipes Definition:Alistipes indistinctus Details Initialisation date:[ ] Meta Information Rank: Species Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - Alistipes indistinctus was the most potent in consuming a wide variety of carbohydrates. [#Diabetes Type 2] - Postprandial blood #Glucose levels were particularly reduced in mice administered with A. indistinctus, #Alistipes finegoldii and #Bacteroides thetaiotaomicron that were fed a high-fat diet. - Insulin tolerance tests also revealed that these strains ameliorated IR, most prominently by A. indistinctus administration. - A. indistinctus administration ameliorated body mass gain, ectopic triglyceride accumulation in the liver and #Glucose intolerance - Serum levels of HDL-C, adiponectin and, to a lesser extent, triglycerides, were also improved in mice that were treated with A. indistinctus. - carbohydrate oxidation was significantly reduced in mice that were treated with A. indistinctus, implying that carbohydrate use is limited. - A. indistinctus administration substantially altered caecal metabolites, characterized by a reduction in several carbohydrates including #Fructose, a lipogenic monosaccharide. - #Fructose was similarly reduced in the serum - The AUC of insulin tolerance test was positively correlated with the caecal monosaccharides #Fructose, #Glucose and #Mannose [#Diabetes Type 2] - A. indistinctus administration improves lipid accumulation and thereby Insulin Resistance, while simultaneously reducing intestinal monosaccharide levels. [1.2] - decreased A. indistinctus was associated with enhanced risk of #Hyperuricemia. [#Hyperuricemia] [#Uric acid] - #Hippuric acid functioned as the key microbial effector of A. indistinctus to lower UA. [#Uric acid] - Replenishment of A. indistinctus and #Hippuric acid alleviated #Hyperuricemia via enhancing ABCG2-mediated intestinal UA excretion. [#Hyperuricemia] [#Uric acid, #Urolithin A] - Alistipes indistinctus (A. indistinctus) was found to be a keystone bacterium for maintaining optimal UA > lower UA. [1.3] [#Diabetes Type 2] - #Bacteroidales — particularly Alistipes indistinctus — could metabolise the monosaccharides accumulated in the faeces of people with IR. [#Diabetes Type 2] - Transfer of IS-associated bacteria (Alistipes indistinctus) reduced blood #Glucose and faecal monosaccharide levels, improved lipid accumulation and ameliorated IR.References Notes[ ]
