Methionine {90000531} Record Keys Parent:[ ] Definition:Methionine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - High levels of #Homocysteine enhanced the #Dementia risk attributed to #Air Pollution, while high methionine concentrations reduced this risk. [1.2] [#Attention Deficit Hyperactivity Disorder] - S-adenosyl-L-methionine supplementation significantly improves ADHD [1.3] [#Rheumatoid Arthritis] [#Eggerthella lenta] [#Tryptophan] - Increased proportion of E. lenta led to a decrease in metabolites, N-acetylglutamine, deoxycarnitine, gamma glutamylmethionine, Trp, N-acetyltryptophan, and methionine, which supports our recent data in patients with RA where an increase in these metabolites was associated with a decrease in disease severity [#Rheumatoid Arthritis] - Diet with high methionine has been shown to attenuate arthritic severity in rats. [1.4] [#Colorectal cancer, #Hepatocellular cancer] - Elevated methionine adenosyl transferase 2A (MAT2A) levels were observed in various types of #Cancer, including CRC, hepatocellular carcinoma (HCC) [#Colorectal cancer] - #Methanethiol as a biomarker for non-invasive early #Cancer detection. - Commensal #Bacteria residing in the colonic lumen can convert dietary methionine to #Methanethiol through MGL-catalyzed α,γ-elimination and γ-replacement reactions. - #Fusobacterium nucleatum, #Citrobacter freundii, #Morganella morganii,and several #Proteus species have been reported to contribute to intestinal #Methanethiol production [#Hydrogen sulfide] - In #Cancer patients, endogenous synthesis of #Methanethiol may substantially increase due to elevated levels of metabolites, such as methionine (Met), #Glucose (Glc), H2S, and SAM, in tumor cells. - The uptake of #Glucose and methionine is often elevated in #Cancer cells due to the upregulation of the respective transporters [1.5] - #Vitamin B12-producing bacteria that colonize the intestine can modulate excitatory cholinergic signalling and behaviour in the host #Caenorhabditis elegans. - #Vitamin B12 reduces cholinergic signalling in the nervous system through rewiring of the methionine (Met)/#S-adenosylmethionine cycle in the intestine. References Notes[ ]
