Methanethiol {90000661} Record Keys Parent:[ ] Definition:Methanethiol Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Colorectal cancer] - Methanethiol as a biomarker for non-invasive early #Cancer detection. - Commensal #Bacteria residing in the colonic lumen can convert dietary #Methionine to methanethiol through MGL-catalyzed α,γ-elimination and γ-replacement reactions. - #Fusobacterium nucleatum, #Citrobacter freundii, #Morganella morganii,and several #Proteus species have been reported to contribute to intestinal methanethiol production [#Hydrogen sulfide] - In #Cancer patients, endogenous synthesis of methanethiol may substantially increase due to elevated levels of metabolites, such as #Methionine (Met), #Glucose (Glc), H2S, and SAM, in tumor cells. - Elevated methanethiol concentrations were also found in the exhaled breath of persons diagnosed with #Oral squamous cell carcinoma, probably deriving from the high endogenous synthesis in the tumor tissue.References Notes[ ]
