Histidine {90000273} Record Keys Parent:[ ] Definition:Histidine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:Amino acid Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Autism] - Autistic children were less likely to consume foods high in #Glutamic acid, serine, #Choline, #Phenylalanine, #Leucine, #Tyrosine, #Valine and histidine, all compounds involved in neurotransmitter biosynthesis [1.2] [#Diabetes Type 2] - CACS-associated species were also found positively associated with #Imidazole propionate, a microbially derived metabolite from histidine, reported to impair #Glucose metabolism. [1.3] [#Diabetes Type 2] - Histidine is the source #Imidazole propionate metabolite. It is negatively correlated with diabetes. - It hampers #Glucose tolerance, insulin signaling, #Glucose metabolism disorder, and causes systemic inflammation. [1.4] - Metabolites associated with #Peanut #Allergy development clustered within the histidine metabolism pathway. - Positive correlations between microbiota, #Butyrate, and #Isovalerate and negative correlations with #Histamine marked the #Peanut #Allergy-free network. [1.5] [#Diabetes Type 2] - #Imidazole propionate is produced at higher concentrations from histidine in a gut simulator when fecal microbiota from T2DM patients is used, and that it impairs #Glucose tolerance when administered to mice. - #Histamine, a potent vasodilator, is produced during histidine catabolism. References Notes[ ]
