Tyramine {90000363}

Record Keys


Parent:[  ]
Definition:
Tyramine
Queue:[  ]

Details


Initialisation date:[  ]
Specification:
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Source:
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Meta Information


Structural Type:[  ]
Functional Type:
Neurotransmitter
Function:[  ]

Notes:


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Shared Reference Notes


  • [1.1] [#Escherichia coli] [#Infants
    - Unique infant microbe-metabolite associations included positive correlations of #Enterococcus faecalis and E. coli with neurotransmitters tyramine and #Agmatine, respectively
  • [1.2] [#Irritable bowel syndrome
    - IBS was associated with differential abundance of bacterial taxa such as #Bacteroides dorei; metabolites including increased tyramine and decreased gentisate and hydrocinnamate; and transcripts related to fructooligosaccharide and polyol utilization.
  • [1.3] [#α-tocopherol
    - microbial metabolites such as α-tocopherol, tyramine, #p-aminobenzoate, and #Indole impact #Serotonin 5-HT secretion by enteroendocrine cells in the intestine.
  • [1.4
    - Tyramine, #Deoxycholic acid, and #4-aminobenzoic acid have been reported to stimulate #Serotonin synthesis
  • [1.5] [#Aromatic amino acid
    - #Enterococcus species is the main tyramine producers in #Infants’ gut
  • [1.6] [#Diabetes Type 2
    - The #Tyrosine decarboxylase action of bacteria #Ruminococcus gnavus, #Enterococcus faecalis and #Clostridium sporogenes converts #Tyrosine (Tyr) into tyramine. - Its role to improve #Glucose tolerance marked it as a beneficial metabolite to T2DM.
  • [1.7
    - TAAR1 is an amine-activated G protein-coupled receptor that is activated by gut microbes-derived aromatic trace amines including #Tryptamine, #Phenethylamine, and tyramine in gut
  • [#Ruminococcus gnavus] - Among these #Tryptamine and #Phenethylamine-producing bacteria species, R. gnavus has the highest catalytic ability to transform aromatic amino acids into aromatic trace amines (#Tryptamine, tyramine, and #Phenethylamine) compared with other bacteria specie
  • [1.8] [#Allergy
    - Several maturation-dependent metabolites were disturbed in #Children who developed allergies with three biogenic amines, namely #Phenylethylamine, #Tryptamine, and tyramine, also demonstrating high correlations with disrupted microbial pathways. - This Trace amines (TAs) have a very high affinity for TA-associated receptors (TAARs), a class of G-coupled protein receptors found on both intestinal and immune cells, and TAAR ligation has been demonstrated to increase intestinal cell oxidative stress and immune cell activation. - their accumulation promotes bacterial adherence to intestinal cells, likely perpetuating this inflammatory response
  • [1.9
    - #Tyrosine catabolism generates tyramine, a neurotransmitter that promotes #Norepinephrine release, resulting in peripheral vasoconstriction, increased blood #Glucose levels, cardiac output, and respiration. - Tyramine also promotes microbe adherence to enterocytes and modulates subsequent cytokine signaling by enterocytes

References Notes


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