Xanthohumol {90000201}

Record Keys
Parent:[  ]
Definition:
Xanthohumol
Queue:[  ]

Details
Initialisation date:
2021-09-14
Specification:
[  ]
Source:
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Meta Information
Structural Type:[  ]
Functional Type:
Energy Source
Function:
Anti-obesity

Notes:

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Shared Reference Notes

  • [1.1] [#Xanthohumol supplementation] 
    - XN supplementation > decreased plasma insulin concentrations > improved Insulin Resistance. - The intestinal microbiota > metabolizes XN into bioactive compounds, including dihydroxanthohumol > anti-obesity. - XN > increased the relative abundance of three bacteria, Akkermansia muciniphila, Parabacteroides goldsteinii and Alistipes finegoldii.
  • [1.2] 
    - some of the positive outcomes of XN are accomplished by increasing #Akkermansia muciniphila, which we also found increased by TXN
  • [#Metabolic associated fatty liver disease] - XN also exhibits hepatoprotective effects in animal models of MAFLD and other liver-damaging conditions
  • [#Metabolic Dysfunction-associated Steatohepatitis] - XN and even more so, TXN, attenuates hepatosteatosis by acting as antagonists of PPARγ
  • [#Metabolic syndrome] - Xanthohumol (XN) and its derivatives mitigate diet-induced #Obesity-related characteristics of MetS in mice by improving impaired #Glucose and lipid metabolism
  • - TXN treatment also reduced levels of inflammation-inducing microbes, such as #Oscillibacter valericigenes, that lead to adverse metabolic phenotypes.
  • - TXN attenuates macrophage inflammatory processes in adipose tissue.

References Notes

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Common References

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