Xanthohumol {90000201} Record Keys Parent:[ ] Definition:Xanthohumol Queue:[ ] Details Initialisation date:2021-09-14 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:Energy Source Function:Anti-obesity Notes: [ ]Shared Reference Notes [1.1] [#Xanthohumol supplementation] - XN supplementation > decreased plasma insulin concentrations > improved Insulin Resistance. - The intestinal microbiota > metabolizes XN into bioactive compounds, including dihydroxanthohumol > anti-obesity. - XN > increased the relative abundance of three bacteria, Akkermansia muciniphila, Parabacteroides goldsteinii and Alistipes finegoldii. [1.2] - some of the positive outcomes of XN are accomplished by increasing #Akkermansia muciniphila, which we also found increased by TXN [#Metabolic associated fatty liver disease] - XN also exhibits hepatoprotective effects in animal models of MAFLD and other liver-damaging conditions [#Metabolic Dysfunction-associated Steatohepatitis] - XN and even more so, TXN, attenuates hepatosteatosis by acting as antagonists of PPARγ [#Metabolic syndrome] - Xanthohumol (XN) and its derivatives mitigate diet-induced #Obesity-related characteristics of MetS in mice by improving impaired #Glucose and lipid metabolism - TXN treatment also reduced levels of inflammation-inducing microbes, such as #Oscillibacter valericigenes, that lead to adverse metabolic phenotypes. - TXN attenuates macrophage inflammatory processes in adipose tissue. References Notes[ ]
