Mannose {90000519}

Shared Reference Notes

• [1.1] [#Cancer] 
  - the large influx of mannose exceeding its metabolic capacity induced metabolic remodeling, leading to the generation of slow-cycling cells with limited deoxyribonucleoside triphosphates (dNTPs). - This metabolic remodeling impaired dormant origin firing required to rescue stalled forks by cisplatin, thus exacerbating replication stress.
• [1.2] [#Crohn’s disease] [#Escherichia coli, #Saccharomyces cerevisiae] 
  - CD patients have increased serum titers of antibodies against the E. coli membrane porin C (#OmpC), yeast S. cerevisiae mannose epitopes (ASCA) and bacterial flagellins (CBir) and both the presence and titers of these antibodies are associated with disease severity.
• [1.3] 
  - mannose can reduce colonization of pathogens by promoting mannose adhesion to #Salmonella. Mannose binds to #Salmonella via type 1 fimbriae
• [1.4] 
  - #Glucose, mannose and glucosamine were preferentially consumed by #Bacteroidales compared with the other orders, whereas #lactulose was mainly produced by #Eubacteriales
• [#Diabetes Type 2] [#Alistipes indistinctus] - Postprandial blood #Glucose levels were particularly reduced in mice administered with A. indistinctus, #Alistipes finegoldii and #Bacteroides thetaiotaomicron that were fed a high-fat diet. - Insulin tolerance tests also revealed that these strains ameliorated IR, most prominently by A. indistinctus administration. - A. indistinctus administration ameliorated body mass gain, ectopic triglyceride accumulation in the liver and #Glucose intolerance - Serum levels of HDL-C, adiponectin and, to a lesser extent, triglycerides, were also improved in mice that were treated with A. indistinctus. - carbohydrate oxidation was significantly reduced in mice that were treated with A. indistinctus, implying that carbohydrate use is limited. - A. indistinctus administration substantially altered caecal metabolites, characterized by a reduction in several carbohydrates including #Fructose, a lipogenic monosaccharide. - #Fructose was similarly reduced in the serum - The AUC of insulin tolerance test was positively correlated with the caecal monosaccharides #Fructose, #Glucose and mannose
• [1.5] [#Diabetes Type 2, #Metabolic syndrome] 
  - Host-accessible monosaccharides such as #Fructose, #Galactose, mannose and #Xylose were increased in people with Insulin Resistance and MetS. The excess monosaccharides could promote lipid accumulation and activate immune cells, leading to an increased pro-inflammatory cytokine response in the host.
• [1.6] [#Oral squamous cell carcinoma] 
  - #Pancreatic Cancer > the mannose-binding #Lectin, which binds specifically to the #Glycans on the fungal wall, was activated mainly by the #Malassezia genus, showing potential for tumor formation. - the presence of #Malassezia sp. in OSCC is associated with a favorable prognosis

References Notes