Polyphenols ⇒ Resveratrol {90000142}

Shared Reference Notes

• [1.1] 
  - Resveratrol exerts antioxidant, antinflammatory and maintains cellular proteostasis and mitochondrial function.
• [1.2] 
• [1.3] [#Bifidobacterium infantis] 
  - Bifidobacteria infantis and #Lactobacillus acidophilus can hydrolyze the glucoside moieties of plant glycosydes from the resveratrol precursor #Piceid to produce resveratrol.
• [1.4] [#Epigallocatechin gallate, #Lipopolysaccharide] 
  - Similar to EGCG, resveratrol was shown in neuron-glial primary cultures to inhibit LPS-induced microglial activation and subsequent production of TNFα, #Nitric Oxide and IL-1β likely through modulation of inflammasome signaling
• [#Polyphenols] - Dietary Polyphenol Preparation (BDPP) containing GSPE, concord #Grape juice and resveratrol was shown to attenuate #Sleep Deprivation-induced contextual memory deficits.
• - resveratrol reduced hypoxia-induced microglial activation in BV-2 cells, consequently reducing proinflammatory factor release by inhibiting hypoxia-induced NF-κB inhibitor (IkB)-α degradation
• [1.5] [#Flavonoid] 
  - Flavonoids derived from fruits and vegetables such as quercertin and resveratrol have been identified as #AHR ligands
• [1.6] [#Diabetes Type 2] 
  - Resveratrol also showed promising potential for the treatment of #Diabetic ulcers. - Resveratrol prevented #Hyperglycemia-induced endothelial dysfunction and angiogenic impairment by activating endothelial SIRT1 and promoting forkhead box O1 (FOXO1) degradation, following a de-repression of c-Myc expression.
• [#Diabetes Type 2, #Obesity] - Resveratrol mimics #Caloric restriction via the activation of #Sirtuin 1 (SIRT 1) resulting in improved exercise performance and insulin sensitivity, as well as showing body fat-lowering effects by inhibiting adipogenesis, and increasing lipid mobilisation in adipose tissue.
• [#UV radiation] - Among these diverse biological effects of resveratrol, the antioxidant properties are most prominent. - Resveratrol has been shown to protect cells against #Hydrogen peroxide-induced #Oxidative stress, as well as UV-irradiation-mediated cell death.
• [#Metabolic syndrome] -resveratrol > #Glucose and lipid homeostasis improvement and a reduction in fat mass, blood pressure, low-grade inflammation, and #Oxidative stress.
• - Resveratrol (3,5,4′-trihydroxy-trans-stilbene) belongs to the stilbenoid group of #Polyphenols. - resveratrol > diverse biological activities, including antioxidant, anti-inflammatory, antiobesity, and anticancer properties.
• [#Psoriasis] - Resveratrol also targets toll-like receptor (TLR) signalling, such as TLR2, TLR3, and TLR4 signalling.9-13 In skin, resveratrol reduces imiquimod-induced, TLR7, TLR8, TLR9-mediated, psoriatic inflammation in animal models, most likely via interfering with NF-kB activation.
• - Resveratrol serves as a chemopreventive agent and displays chemotherapeutic properties that are attributed to its antioxidant, anti-inflammatory, proapoptotic, and antiproliferative features.
• - Resveratrol is supposed to target intracellular signalling pathway components including regulators of cell survival and apoptosis, pro-inflammatory mediators, and key components of tumour angiogenesis and metastasis by interfering with a distinct set of transcription factors, upstream kinases, and their regulators
• - anti-inflammatory and wound healing effects of resveratrol depend rather on their interaction with epidermal growth factor receptor (EGFR)-controlled cytoplasmic and nuclear pathways than on their direct antioxidant and free radical scavenging activity
• - During the regular use of topical resveratrol , a 20% increase in skin hydration was detected after 2 weeks of treatment. - resveratrol is able to replenish and modify the natural water-lipid layer and intercellular cement in skin deeper layers, leading to an inhibition of transepidermal water loss (TEWL)
• [#Grape, #Peanut, #Soybean] - Resveratrol has been found in more than 70 different plant species and important dietary sources are grapes (skin and seeds), red wine, peanuts, and soy.
• [#Skin aging] - night-time topical antioxidant containing resveratrol, baicalin, and #Vitamin E for 12 weeks. - significant increase in collagen type II alpha 1 gene expression. - Supported with a clinical improvement in elasticity and skin thickness as measured by ultrasound.
• [#Skin aging] [#UV radiation] - In mice > oral or topical administration of resveratrol resulted in a suppression of UVB-induced epidermal thickening.
• [#Skin scar] - resveratrol treatment in human hypertrophic scar-derived fibroblasts (HSFBs) suppressed cell proliferation, which lead to cell cycle arrest and induced apoptosis in a dose- and time-dependent manner. - Treatment with resveratrol for 24 hours achieved an antiproliferative effect through an induction of apoptosis. - The effect was enhanced with longer resveratrol treatment duration and higher resveratrol concentration. - resveratrol downregulated Type I and III procollagen mRNA expression in HSFBs, which resulted in a decreased collagen deposition. - As an agonist to SIRT 1, resveratrol downregulated mRNA levels of collagen I, collagen III, and α-smooth muscle actin (α-SMA) due to upregulation of SIRT1 in a dose-dependent manner.
• [#Skin wound] - topical resveratrol treatment exhibited a significant antimicrobial efficacy against #Staphylococcus aureus, #Pseudomonas aeruginosa, and #Candida albicans, which are discussed as significant pathogens in the context of non-healing wounds. - Resveratrols’ antimicrobial effects seemed to be even superior than some commercial antimicrobial (Levomecol) and antifungal (Clotrimazole) ointments.
• [#Skin wound] - anti-inflammatory and wound healing effects of resveratrol depend rather on their interaction with epidermal growth factor receptor (EGFR)-controlled cytoplasmic and nuclear pathways than on their direct antioxidant and free radical scavenging activity. - significantly improved wound healing following resveratrol application based on antioxidant activity. - resveratrol induces vascular endothelial growth factor (VEGF) expression and subsequently regulates angiogenesis.
• [#Skin wound] [#Sirtuin] - proangiogenic properties of resveratrol> activation of SIRT1 > SIRT1 is associated with the induction of angiogenesis, fibroplasia, and collagen organisation.

References Notes