Homovanillic acid {90000704} Record Keys Parent:[ ] Definition:Homovanillic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Bifidobacterium longum, #Roseburia intestinalis] - R. intestinalis does not directly produce HVA, it enhances B. longum abundance, leading to HVA generation. [#Bifidobacterium longum, #Roseburia intestinalis] - Administering HVA, B. longum, or R. intestinalis to mouse models with chronic unpredictable mild stress (CUMS) and corticosterone (CORT)-induced #Depression significantly improved depressive symptoms. - HVA inhibited synaptic autophagic death by preventing excessive degradation of microtubule-associated protein 1 light chain 3 (LC3) and SQSTM1/p62 proteins, protecting hippocampal neurons’ presynaptic membrane.References Notes[ ]
