Microbiome & Chronic Diseases

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Acidaminococcaceae ⇒ Malassezia {10001586}

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Shared Reference Notes

  • [1.1] [#Atopic Dermatitis
    - Malassezia spp. colonization increases with AD severity and has been detected in up to 90% of skin lesions.
  • [1.2] [#Adult age
    - Multiple #Candida spp. were at higher relative abundance in #Children than adults, while Malassezia and certain food-associated fungi were lower in #Children.
  • [1.3] [#Colorectal cancer
    - Malasseziomycetes and decreased Saccharomycetes were observed in CRC patients. The distribution of fungal genera #Aspergillus, Malassezia, #Rhodotorula, Pseudogymnoascus, Kwoniella, Talaromyces, Debaryomyces, Moniliophthora, Pneumocystis, and Nosemia was altered in CRC.
  • [#Pancreatic Cancer] - in a mouse model of PDA, Malassezia from the colon infiltrated and accelerated PDA, a condition that was reversed with antifungal treatment.
  • [1.4] [#Amyotrophic lateral sclerosis
    - Tissue sections from different regions of the CNS of ALS patients contain fungi. - fungal structures such as yeast and hyphae in the motor cortex, the medulla and the spinal cord, in eleven patients with ALS. - Some fungal structures were localized intracellularly and even intranuclearly, indicating that this infection is not the result of post-mortem colonization. - PCR analysis and next generation sequencing of DNA extracted from frozen neural tissue identified a variety of fungal genera including #Candida, Malassezia, #Fusarium, #Botrytis, #Trichoderma and #Cryptococcus.

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