Acidaminococcaceae ⇒ Malassezia {10001586}

Shared Reference Notes

• [1.1] [#Pancreatic Cancer] 
  -pancreatic ductal adenocarcinoma (PDA) tumours in humans and mouse models of this #Cancer displayed an increase in #Fungi of about 3,000-fold compared to normal pancreatic tissue. - the fungal community that infiltrated PDA tumours was markedly enriched for Malassezia spp. in both mice and humans. - Ablation of the mycobiome was protective against tumour growth in slowly progressive and invasive models of PDA, - repopulation with a Malassezia species—but not species in the genera Candida, Saccharomyces or Aspergillus—accelerated oncogenesis. - ligation of mannose-binding lectin (MBL), which binds to glycans of the fungal wall to activate the complement cascade, was required for oncogenic progression, - Deletion of MBL or C3 in the extratumoral compartment—or knockdown of C3aR in tumour cells—were both protective against tumour growth.
• [1.2] [#Atopic Dermatitis] 
  - Malassezia spp. colonization increases with AD severity and has been detected in up to 90% of skin lesions.
• [1.3] [#Adult] 
  - Multiple #Candida spp. were at higher relative abundance in #Children than adults, while Malassezia and certain food-associated fungi were lower in #Children.
• [1.4] [#Colorectal cancer] 
  - Malasseziomycetes and decreased Saccharomycetes were observed in CRC patients. The distribution of fungal genera #Aspergillus, Malassezia, #Rhodotorula, Pseudogymnoascus, Kwoniella, Talaromyces, Debaryomyces, Moniliophthora, Pneumocystis, and Nosemia was altered in CRC.
• [#Pancreatic Cancer] - in a mouse model of PDA, Malassezia from the colon infiltrated and accelerated PDA, a condition that was reversed with antifungal treatment.
• [1.5] [#Amyotrophic lateral sclerosis] 
  - Tissue sections from different regions of the CNS of ALS patients contain fungi. - fungal structures such as yeast and hyphae in the motor cortex, the medulla and the spinal cord, in eleven patients with ALS. - Some fungal structures were localized intracellularly and even intranuclearly, indicating that this infection is not the result of post-mortem colonization. - PCR analysis and next generation sequencing of DNA extracted from frozen neural tissue identified a variety of fungal genera including #Candida, Malassezia, #Fusarium, #Botrytis, #Trichoderma and #Cryptococcus.
• [1.6] [#Pancreatic Cancer] 
  - Malassezia > new pathogenic roles in #Seborrheic dermatitis, #Psoriasis, #Crohn’s disease, and pancreatic ductal carcinoma.
• [1.7] 
• [1.8] [#Gastric carcinoma] 
  - Malassezia was significantly more abundant in the GC group than in the control group at the genus level, which is the most common fungal genus of human skin and can also colonize the gut
• [1.9] [#Oral squamous cell carcinoma] 
  - #Pancreatic Cancer > the #Mannose-binding #Lectin, which binds specifically to the #Glycans on the fungal wall, was activated mainly by the Malassezia genus, showing potential for tumor formation. - the presence of Malassezia sp. in OSCC is associated with a favorable prognosis

References Notes