Debaryomyces ⇒ Debaryomyces hansenii {10001693} Record Keys Parent:Debaryomyces Definition:Debaryomyces hansenii Details Initialisation date:[ ] Meta Information Rank: Species Domain:Fungi Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Crohn’s disease] - Debaryomyces hansenii preferentially localized to and was abundant within incompletely healed intestinal wounds of mice and inflamed mucosal tissues of CD human subjects. - D. hansenii cultures from injured mice and inflamed CD tissues impaired colonic healing when introduced into injured conventionally raised or gnotobiotic mice. - Mechanistically, D. hansenii impaired mucosal healing through the myeloid cell–specific type 1 interferon–CCL5 axis. [1.2] [#Crohn’s disease, #Ulcerative Colitis] - patients with isolated ileal CD showed a marked increased abundance in D hansenii, a species previously related to CD pathogenesis. - D hansenii is enriched in inflamed ileal biopsies of patients with CD and impairs mucosal healing. - an enrichment in Debaromyces in patients with UC.References Notes[ ]
