Microbiome & Chronic Diseases

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Antimicrobial peptides {90000176}

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Antimicrobial peptides
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cathelicidin, psoriasin, RNAse7 and dermcidin

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Shared Reference Notes

  • [1.1
    - Human hair follicle may manage its microbiome via the regulated production of antimicrobial peptides (such as cathelicidin, psoriasin, RNAse7 and dermcidin) by HF keratinocytes,
  • [1.2] [#Atopic Dermatitis
    - Atopic skin exhibits lower levels of certain HDPs such as #Dermcidin, human beta-defensin-2 (hBD-2), human beta-defensin-3 (hBD-3), and #Cathelicidin, as well as increased expression of #RNAse7 and S100A7
  • [#Atopic Dermatitis] - Patients with AD exhibit decreased expression of antimicrobial peptides (AMPs) which is linked to increased colonization by #Staphylococcus aureus.
  • [#Natural Skin Microbiome] [#Cathelicidin] - Host-derived AMPs, also known as host defence peptides (HDP)s are either constitutively produced by keratinocytes and immune cells or induced in response to stimuli such as pathogen-associated molecular patterns (PAMPs) or inflammatory cytokines. Some important classes of HDPs include RNases, defensins, cathelicidins, dermcidin, and S100 class peptides. - Some important classes of HDPs include RNases, defensins, cathelicidins, dermcidin, and S100 class peptides.
  • - HDPs are well-known for their immunomodulatory and barrier-improving properties and play a critical role in the pathogenesis of diseases such as #Psoriasis and polymorphic light eruption underscoring the versatile role of HDPs in skin physiology
  • [1.3
    - Paneth cells in the gut secrete several antimicrobial peptides into the lumen to regulate the microbiota, as well as #Pancreatic polypeptide YY (PYY). - The Paneth cell–derived PYY was full length, unlike the endocrine form, and although it had some antibacterial activity, it was most effective at inhibiting the ubiquitous gut fungus #Candida albicans from transforming from the commensal yeast form into the invasive hyphal form ( against virulent #Candida albicans hyphae—but not the yeast form).
  • [1.4
    - AMPs produced by #Lactobacillus plantarum were capable of modulating cytokine production in PBMCs, with an increase in the production of the anti-inflammatory cytokines #IL-10 and #IL-12 by over 10-fold.
  • [#Staphylococcus aureus] - #Staphylococcus epidermidis produces #Epidermin or the #Hominicin produced by #Staphylococcus hominis, with both AMPs being extremely effective against S. aureus
  • [1.5] [#Systemic lupus erythematosus, #antiphospholipid syndrome] [#Gingerols
    - 6-gingerol, the most abundant bioactive phytochemical in #Ginger root, inhibited neutrophil phosphodiesterase (PDE) activity, boosting intracellular cyclic AMP (cAMP) levels and thereby counteracting neutrophil hyperactivity in mouse models of APS and lupus

References Notes

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Common References