Secondary bile acids ⇒ Ursodeoxycholic acid | Metabolome

Secondary bile acids ⇒ Ursodeoxycholic acid {90000394}

Notes:

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[1.1] [#Primary bile acids, #Secondary bile acids]
- Primary #Bile Acids are conjugated in several different forms and secreted into the intestine. - a small portion (~5%) of the Primary #Bile Acids (about 200 to 800 mg daily in humans) escapes the reabsorption in Ileum and reaches the colon where gut bacteria convert them into secondary #Bile Acids (SBAs), such as #Deoxycholic acid (DCA), ursodeoxycholic acid (UDCA), and #Lithocholic acid (LCA). - majority (90% to 95%) of SBAs are reabsorbed into colonocytes to return to the liver for detoxification and recycling.
[#Colon adenomas, #Colorectal cancer] [#Deoxycholic acid, #Secondary bile acids] - UDCA has microbiome-changing and DCA‐lowering prpperties. - treatment with UDCA, decreased recurrence of adenomas with high-grade dysplasia. - DCA also stimulates the uptake of polyamines in CRC cells, which also have tumorigenic effects.
[1.2] [#Dementia with Lewy bodies (DLB)]
- #Ruminococcus torques and #Collinsella are also major #Secondary bile acids-producing bacteria, we quantified fecal bile acids and found that the production of ursodeoxycholic acid (UDCA) was high in DLB.

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