High ambient temperature {51111422} Record Keys Definition:High ambient temperature Queue:[ ] Details Initialisation date:[ ] Specification: [ ] Meta Information Type:[ ] Host:[ ] Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] - high ambient temperature of 36 °C increases host resistance to viral pathogens including #Influenza virus and severe acute respiratory syndrome #Coronavirus 2 (SARS-CoV-2). - High heat-exposed mice increase basal body temperature over 38 °C to enable more #Bile Acids production in a gut microbiota-dependent manner. - The gut microbiota-derived #Deoxycholic acid (DCA) and its plasma membrane-bound receptor Takeda G-protein-coupled receptor 5 (TGR5) signaling increase host resistance to #Influenza virus infection by suppressing virus replication and neutrophil-dependent tissue damage. - the DCA and its nuclear farnesoid X receptor (FXR) agonist protect Syrian hamsters from lethal SARS-CoV-2 infection. certain #Bile Acids are reduced in the plasma of COVID-19 patients who develop moderate I/II disease compared with the minor severity of illness group. [1.2] - #Lachnoclostridium is a genus of gram-positive, obligate anaerobic, spore-forming, motile bacteria. - Organisms in this genus can grow in moderate ‘mesophilic’ as well as in extremely high ‘thermophilic’ temperatures [#High temperature and humidity] - High-temperature and humidity conditions > decrease in #Lithocholic acid levels References Notes[ ]
