Taurodeoxycholic acid (TDCA) {90000389} Record Keys Parent:[ ] Definition:Taurodeoxycholic acid (TDCA) Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Celiac Disease] [#Clostridium cluster XIVa] - 26 plasma metabolites, five cytokines, and one chemokine were significantly altered in CD progressors at age 5. - CD > 2-fold increase in TDCA. - TDCA feeding alone stimulates an inflammatory immune response in the small intestines of C57BJ/6 mice and causes villous atrophy, the hallmark of CD. - TDCA, a microbiota-derived metabolite, enriched in CD progressors’ plasma, has the potential to drive inflammation in the small intestines and enhance CD pathogenesis. - TDCA, is a conjugated bile acid that is mainly produced by gut microbes, particularly Clostridium XIVa and Clostridium XI, with 7-α-dehydroxylation of taurocholic acid and cholic acid. - TDCA was previously shown to be a proinflammatory metabolite. - several Clostridium XIVa ASVs were significantly more abundant in CD samples, especially at age 5. - Clostridium XIVa ASVs were highly targeted by IgA in CD progressors.References Notes[ ]
