Polysaccharide A {60000091} Record Keys Parent:[ ] Definition:Polysaccharide A Queue:[ ] Details Initialisation date:2020-10-06 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Immun regulator, Anti-inflammatory Notes: [ ]Shared Reference Notes [1.1] - Polysaccharide A produced by Bacteroides fragilis direct the immune system via its ability to direct the development of CD4+ T cells. [1.2] - #Bacteroides fragilis metabolite polysaccharide A has anti-inflammatory properties, [1.3] - polysaccharide A, a Toll-like receptor (TLR) 2 ligand, of #Bacteroides fragilis, induces Treg cells and suppresses pro-inflammatory TH17 cell responses, thus promoting gut immune tolerance and host–microbial symbiosis. [1.4] [#Inflamatory bowel disease] - the promoter of polysaccharide A (PSA) of #Bacteroides fragilis, which induces regulatory T cells (Tregs) and ameliorates experimental #Colitis was mostly oriented “OFF” in IBD patients, which correlated with increased B. fragilis-associated bacteriophages. - in mice colonized with a healthy human microbiota and B. fragilis, induction of #Colitis caused a decline of PSA in the “ON” orientation that reversed as inflammation resolved. - Monocolonization of mice with B. fragilis revealed that bacteriophage infection increased the frequency of PSA in the “OFF” orientation, causing reduced PSA expression and decreased Treg cells.References Notes[ ]
