Proline {90000312} Record Keys Parent:[ ] Definition:Proline Queue:[ ] Details Initialisation date:2022-06-15 Specification: [ ]Source: [ ] Meta Information Structural Type:Amino acid Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Lactobacillus plantarum] - High proline consumption was the dietary factor with the strongest impact on #Depression. - Proline supplementation in mice exacerbated #Depression along with microbial translocation. - RNAi-mediated knockdown of proline and GABA transporters in Drosophila and mono-association with L. plantarum, a high GABA producer, conferred protection against #Depression-like states. [1.2] [#Covid-19] - increased levels of proline associated with collagen metabolism in long COVID patients. - The #Glutamate/P5C synthase pathway in the intestine is responsible for most of the proline synthesis in the body. - The increased levels of proline may arise from #Arginine or #Glutamine pathways, potentially in response to hypoxia or tissue damage. - Elevated blood levels of hydroxyproline have been proposed as a biomarker for diseases characterized by #Fibrosis, indicating an increased demand for proline in collagen synthesis. [1.3] [#Drug-resistant Epilepsy] [#Keto diet] - Microbial genes related to fatty acid β-oxidation, 2-methylcitrate cycle, glycol metabolism, and proline biosynthesis were more highly represented in the gut microbiota of epileptic #Children after treatment with the KD compared to their internal pre-treatment controlsReferences Notes[ ]
