Disease ⇒ Essential tremor {40000650} Record Keys Type:Disease Parent:[ ] Definition:Essential tremor Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - transplantation of gut microbiota obtained from patients with ET led to prolonged tremors and impaired mobility in murine models of ET - The γ-aminobutyric acid (#GABA) hypothesis posits a role of #GABA deficiency in the central nervous system in the pathogenesis and progression of essential tremor. - gut microbiota of patients with ET had a lower #GABA-producing capacity. - degeneration of the GABAergic neurons in the cerebellum and a reduction in the concentrations of #GABA in the cerebrospinal fluid were observed in patients with ET [#Lactobacillus plantarum] - administering the high-#GABA-producing L. plantarum strain L5 significantly ameliorated the tremors in ET mice by reshaping the gut microbial composition, enhancing the #GABA-producing capacity of the mucosa-associated microbiota, and elevating the #GABA concentrations in the cerebellum. - supplementation of L5 did not lead to any conspicuous increase in the plasma concentrations of #GABA in mice. - #GABA synthesized by the intestinal L5 was conveyed to the brain via the “enteric nervous system–vagus nerve–brain” axis and subsequently relieved the tremor. - the administration of L5 significantly elevated the relative abundance of several probiotics (e.g., Lactobacillus and Akkermansia), improved the small intestinal barrier, and attenuated neuroinflammation in ET mice.References Notes[ ]
