Microbiome & Chronic Diseases

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Staphylococcus aureus ⇒ Staphylococcus {10000114}

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Staphylococcus aureus


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Shared Reference Notes

  • [1.29
    - Staphylococcal bacterial infection and bacterial toxins can trigger an immune response that leads to the production of dietary-antigen-specific IgE antibodies in mice, which are limited to the intestine. - Following subsequent oral ingestion of the respective dietary antigen, an IgE- and mast-cell-dependent mechanism induced increased visceral pain. -This aberrant pain signalling resulted from histamine receptor H1-mediated sensitization of visceral afferents. - Injection of food antigens (gluten, wheat, soy and milk) into the rectosigmoid mucosa of patients with #Irritable bowel syndrome induced local oedema and mast cell activation.
  • [1.13] [#Cutaneous T-Cell Lymphoma
    - Staphylococcus aureus > contribute to disease progression
  • [1.4] [#Atopic Dermatitis] [#Staphylococcus epidermidis
    - increased abundance of S. aureus with depletion of S. epidermidis and #Corynebacterium spp. among AD patients. - S. epidermidis, a commensal present on non–inflamed skin, appears to be S. aureus best antagonist. - less severe flares of AD had higher counts of S. epidermidis whereas the more severe flares were associated with S. aureus
  • [#Atopic Dermatitis] [#Staphylococcus lugdunensis] - #Staphylococcus hominis, S. lugdunensis and S. epidermidis produce several molecules capable of synergizing the innate antimicrobial response against S. aureus
  • [1.5] [#Atopic Dermatitis
    - samples where S. aureus was highly abundant, lower abundances of S. hominis and Cutibacterium acnes were observed. M. osloensis and M. luteus were more abundant in AD. - The flexures exhibited lower alpha-diversity and were colonized by S. aureus, accompanied by S. epidermidis in lesions. Malassezia species were absent on the neck in AD.
  • [1.2] [#Atopic Dermatitis
    - S. aureus, a dominant species among the family of Staphylococcae, can be 100 times more abundant in AD skin compared to normal healthy skin. - AD is associated with a depletion in the coagulase-negative staphylococcal species (CoNS), such as S. epidermidis, S. hominis, and other skin commensal bacterial communities, including Streptococcus salivarius, Propionibacterium, Streptococcus, Acinetobacter, Corynebacterium, Prevotella and Proteobacteria. - AD patients exhibit abundant S. aureus in their gut microbiota
  • [1.30] [#Natural Skin Microbiome
    - Other Staphylococcus spp. that inhabit the skin of humans, for example #Staphylococcus hominis and #Staphylococcus lugdunensis, may produce antimicrobial peptides that specifically inhibit colonization by S. aureus.
  • [1.31] [#Systemic lupus erythematosus
    - after Staphylococcus aureus was epicutaneously applied on NfkbizΔK5 mice, NfkbizΔK5 mice developed SLE-associated autoantibodies, anti-dsDNA antibodies, anti-Sm antibodies, and glomerulonephritis with IgG deposition. - This staphylococcal skin colonization promoted caspase-mediated keratinocyte apoptosis and neutrophil activation, inducing the interleukin-23 (IL-23)/IL-17 immune response by activating dendritic cells and T cells. - the subcutaneous administration of anti–IL-23p19 and anti–IL-17A antibodies alleviated the systemic autoimmune response.

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