Lipoteichoic acid {90000229} Record Keys Parent:[ ] Definition:Lipoteichoic acid Queue:[ ] Details Initialisation date:2022-01-09 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Pro-inflammatory Notes: [ ]Shared Reference Notes [1.1] [#Bile Acids] - Microbiota > higher levels of the microbiota-derived secondary bile acid #Deoxycholic acid and Gram-positive gut microbial component, lipoteichoic acid > These compounds induced senescence of hepatic stellate cells (HSCs) and the secretion of pro-inflammatory SASP > creating a pro-tumorigenic microenvironment. [1.2] [#Parkinson’s Disease] - increases in gene-families involved in the synthesis of Lipoteichoic acid (LTA), a component of Gram-positive bacteria cell envelope which shares many of the pathogenic properties of LPS. [1.3] - toll-like receptor (TLR)2 signaling, activated by various gram-positive bacterial ligands such as lipoteichoic acid found on #Lactobacillus plantarum strains, is required for the microbiota-mediated protection of the epithelial barrier and formation of tight junctions. [1.4] - #Cancer Tissue > LTA-positive bacteria were almost exclusively found in macrophages [#Melanoma] - lipoteichoic acid (LTA) was detected mainly in melanomas and was largely absent in other tumor types.References Notes[ ]
