IL-12 {90000556} Record Keys Parent:[ ] Definition:IL-12 Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Pro-inflammatory Notes: [ ]Shared Reference Notes [1.1] [#TNF-alfa] - anti-inflammatory cytokines (IL-4 and #IL-10) and proinflammatory cytokines (TNF-a, #IL-1b, #IL-2, #IL-6, #IL-8, IL-12, #IL-17, and #IL-18) are significantly changed by #Lactobacillus rhamnosus GG (LGG) [#TNF-alfa] - #Lactobacillus rhamnosus GG is known to strengthen the gut permeability barrier by fortifying intestinal tight junctions, mucin layer thickness, and antigen-specific immunoglobulin A production. - L. rhamnosus GG administrated participants showed a significant decrease in the serum levels of the pro-inflammatory cytokines (#IL-6, IL-12 p70, and TNF-α). [1.2] [#Lipopolysaccharide, #Short Chain Fatty Acid] - SCFAs, especially #Propionic acid, and #Butyric acid, can inhibit the expressions of cytokines #IL-6 and IL-12 induced by LPS in human mature dendritic cells. [1.3] [#Lipopolysaccharide] - the LPS derived from the feces of mice kept on the #Phytoestrogen-free diet induced significantly higher levels of TNF-α, IL-1β, #IL-6, IL-12/23, and CXCL1 compared to the LPS derived from feces of mice kept on the #Isoflavone-diet. [1.4] [#Antimicrobial peptides] - AMPs produced by #Lactobacillus plantarum were capable of modulating cytokine production in PBMCs, with an increase in the production of the anti-inflammatory cytokines #IL-10 and IL-12 by over 10-fold.References Notes[ ]
