Chlamydiaceae ⇒ Chlamydia {10001014} Record Keys Parent:Chlamydiaceae Definition:Chlamydia Details Initialisation date:[ ] Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Inflamatory bowel disease] - HLA-B27 spondyloarthropathies (SpA) > #Ankylosing spondylitis, #Reactive arthritis, #Psoriatic Arthritis, #Juvenile idiopathic arthritis, inflammatory bowel disease, #Acute anterior uveitis, and undifferentiated SpA > segmented filamentous bacteria (SFB) have been illustrated to be a common culprit in initiating an arthritogenic reaction. - The Th17 response, induced in the mesenteric lymph nodes by dendritic cells, in such patients specifically targets SFB, resulting in a breach in the mucosal barrier. - This is thought to result from cross-reactivity between HLA-B27 and pathogenic surface antigens. - Other enteric gram-negative pathogens, which mimic HLA-B27, associated with SpA and uveitis include #Shigella, Chlamydia and #Yersinia [1.2] [#Cervical cancer] [#Reactive Oxygen Species] - Chlamydia spp. have been described in cervical and #Ovarian cancer > decrease p53 signaling and DNA damage response, in facilitating the pathogen’s intracellular replication, induction of ROS production and DNA damageReferences Notes[ ]
