Short Chain Fatty Acid ⇒ Caproic acid {90000387} Record Keys Parent:Short Chain Fatty Acid Definition:Caproic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Gestational diabetes mellitus (GDM), #Pregnancy] [#Branched-chain amino acids, #Short Chain Fatty Acid] In GDM: - Isobutyric, isovaleric, valeric, and hexanoic acids were significantly higher in the GDM. - #Isobutyric acid significantly correlated with urea and blood glucose at 1 and 2 hours after OGTT; fasting blood glucose, blood glucose at 2 hours after OGTT. - urea/creatinine ratio positively correlated with #Valeric acid. - blood glucose at 2 hours after OGTT positively correlated with caproic acid. - white blood cell count positively correlated with #Propionic acid. - Significantly elevated #Isobutyric acid and isovaleric acid in pregnant women with GDM may be associated with insulin resistance caused by BCFAs. [#Intrahepatic Cholestasis of Pregnancy (ICP), #Pregnancy] [#Short Chain Fatty Acid] In the ICP - isobutyric acids levels were higher, while acetic, propionic, butyric, isovaleric, valeric, and hexanoic acids levels were significantly lower. - #Isobutyric acid and #Hexanoic acid showed significant correlations with each clinical indicator. - Hemoglobin, white blood cells count, albumin, gestational weeks at delivery, fetal birth weight, and BMI were positively correlated with #Hexanoic acid. - total BAs and ALT were negatively correlated with #Hexanoic acid - #Isobutyric acid showed the opposite trend with #Hexanoic acid. - #Valeric acid positively correlated with hemoglobin and negatively correlated with total BA and ALT. - caproic acid and #Isobutyric acid might be potential biomarkers [1.2] [#Autism] [#Isobutyric acid, #Isovaleric acid, #Propionic acid, #Short Chain Fatty Acid, #Valeric acid] - higher levels of propionic and valeric acids as well as the sum of minor SCFA (isobutyric + isovaleric + valeric + caproic acids) were found in ASD at the age 4–7 years, but these differences disappeared at the age of 8–10 year [1.3] [#Short Chain Fatty Acid] - Hexane is commonly used for the extraction of less polar SCFAs, such as caproic acid and caprylic acid.References Notes[ ]
